Molecular structure of Pifithrin-α hydrobromide, CAS Number: 63208-82-1
Pifithrin-α hydrobromide (CAS 63208-82-2)
See product citations (36)
Alternate Names:
Pifithrin-α hydrobromide is also known as PFT-α.
Application:
Pifithrin-α hydrobromide is an inhibitor of p53 that reversibly blocks p53 dependent transcriptional activation and apoptosis.
CAS Number:
63208-82-2
Purity:
≥98%
Molecular Weight:
367.30
Molecular Formula:
C16H18N2OS•HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Pifithrin-α hydrobromide is a reversible inhibitor of p53-mediated apoptosis and p53-dependent gene transcription such as cyclin G, p21/waf1, and mdm2 expression. It enhances cell survival after genotoxic stress such as UV irradiation and treatment with cytotoxic compounds including doxorubicin (sc-280681), etopoxide, paclitaxel, and cytosine-β-D-arabinofuranoside. Additionally, Pifithrin-α is an aryl hydrocarbon receptor (AHR) agonist, which leads to the upregulation of AHR target gene CYP1A1 (EC50 = 1.1 µM). Uses of pifithrin-α hydrobromide extend to the study of cellular resilience and adaptability in response to environmental stresses. Researchers can study how modulation of transcription factor activities can impact cellular decision-making processes, including survival, adaptation, and response to external signals.
Pifithrin-α hydrobromide (CAS 63208-82-2) References
- A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. | Komarov, PG., et al. 1999. Science. 285: 1733-7. PMID: 10481009
- Suppression of p53: a new approach to overcome side effects of antitumor therapy. | Komarova, EA. and Gudkov, AV. 2000. Biochemistry (Mosc). 65: 41-8. PMID: 10702639
- A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide. | Culmsee, C., et al. 2001. J Neurochem. 77: 220-8. PMID: 11279278
- Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism. | Lorenzo, E., et al. 2002. J Biol Chem. 277: 10883-92. PMID: 11779855
- p53 is a determinant of X-linked inhibitor of apoptosis protein/Akt-mediated chemoresistance in human ovarian cancer cells. | Fraser, M., et al. 2003. Cancer Res. 63: 7081-8. PMID: 14612499
- The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon receptor. | Hoagland, MS., et al. 2005. J Pharmacol Exp Ther. 314: 603-10. PMID: 15843497
- Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53. | Sohn, D., et al. 2009. Cell Death Differ. 16: 869-78. PMID: 19229248
- Signalling pathways involved in antitumoral effects of VIP in human renal cell carcinoma A498 cells: VIP induction of p53 expression. | Vacas, E., et al. 2014. Int J Biochem Cell Biol. 53: 295-301. PMID: 24905957
- Semaphorin 3E regulates apoptosis in the intestinal epithelium during the development of colitis. | Eissa, N., et al. 2019. Biochem Pharmacol. 166: 264-273. PMID: 31170375
- The glycoprotein mucin-1 negatively regulates GalNAc transferase 5 expression in pancreatic cancer. | Caffrey, T., et al. 2019. FEBS Lett. 593: 2751-2761. PMID: 31283009
- P53/PANK1/miR-107 signalling pathway spans the gap between metabolic reprogramming and insulin resistance induced by high-fat diet. | Yang, L., et al. 2020. J Cell Mol Med. 24: 3611-3624. PMID: 32048816
- Triptolide enhances lipolysis of adipocytes by enhancing ATGL transcription via upregulation of p53. | Wang, X., et al. 2020. Phytother Res. 34: 3298-3310. PMID: 32614500
- The transcriptional cofactor Jab1/Cops5 is crucial for BMP-mediated mouse chondrocyte differentiation by repressing p53 activity. | Mamidi, MK., et al. 2021. J Cell Physiol. 236: 5686-5697. PMID: 33393086
- p53 Promotes Ferroptosis in Macrophages Treated with Fe3O4 Nanoparticles. | Wu, C., et al. 2022. ACS Appl Mater Interfaces. 14: 42791-42803. PMID: 36112832
- Angiotensin II-induced vascular endothelial cells ferroptosis via P53-ALOX12 signal axis. | Liu, C., et al. 2023. Clin Exp Hypertens. 45: 2180019. PMID: 36860117
Inhibitor of:
53BP2, ASCL5, Bag-5, BC066028, CDIP, D4Wsu53e, FILIA, FOXC1, GS2, GTPBP4, GTPBP6, JMY, LOC645949, LOC646012, MYBBP1A, Olfr607, Olfr640, Olfr641, Olfr642, Olfr643, Olfr644, Olfr645, OTTMUSG00000011285, p53, p53AIP1, p53CSV, Pbx 3, PCDHAC, PIG-U, PIG3, RBQ-3, RNF113A2, Selenoprotein O, Sil, Sva, TBX5, TP53INP1, TP53INP2, TP53TG5, Transcription Factor, translin, Trp53i11, Trp53i13, TSGA10, TTC26, USP53, and ZBED1.Activator of:
ARHGAP42, ATF-5, BC030500, FKBP10, FKBP11, G3BP2, GADD 45β, HspBP1, MDM2, p53RFP, p63, Rad17, RHOBTB1, UBE2H, UNCX, Wig-1, and ZNF512B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Pifithrin-α hydrobromide, 5 mg | sc-45050 | 5 mg | $118.00 | |||
Pifithrin-α hydrobromide, 25 mg | sc-45050A | 25 mg | $287.00 |