Date published: 2026-2-9

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Picramic Acid (CAS 96-91-3)

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Alternate Names:
2-Amino-4,6-dinitrophenol
CAS Number:
96-91-3
Molecular Weight:
199.12
Molecular Formula:
C6H5N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Picramic Acid is an important intermediate in organic synthesis and is in various scientific applications. It serves as a reagent in synthesizing dyes and agrochemicals. It finds application as an analytical reagent for detecting amino acids and proteins. Picramic Acid plays a role in the synthesis of polymers like polyurethanes and polyamides. It acts as an inhibitor of the enzyme tyrosinase, which is involved in the biosynthesis of melanin. Picramic Acid can also reduce the production of nitric oxide and inhibit the activity of enzymes involved in the metabolism of carbohydrates, lipids, and amino acids.


Picramic Acid (CAS 96-91-3) References

  1. Analysis of polynitrophenols and hexyl by liquid chromatography-mass spectrometry using atmospheric pressure ionisation methods and a volatile ion-pairing reagent.  |  Pamme, N., et al. 2002. J Chromatogr A. 943: 47-54. PMID: 11820280
  2. Acute toxicity, distribution, and metabolism of 2,4,6-trinitrophenol (picric acid) in Fischer 344 rats.  |  Wyman, JF., et al. 1992. J Toxicol Environ Health. 37: 313-27. PMID: 1404487
  3. Fate and effects of picric acid and 2,6-DNT in marine environments: toxicity of degradation products.  |  Nipper, M., et al. 2005. Mar Pollut Bull. 50: 1205-17. PMID: 15913666
  4. Environmental process descriptors for TNT, TNT-related compounds and picric acid in marine sediment slurries.  |  Yost, SL., et al. 2007. Mar Pollut Bull. 54: 1262-6. PMID: 17512956
  5. Tissue distribution and elimination of N-methyl-N-2,4,6-tetranitroaniline (tetryl) in rats.  |  Myers, SR. and Spinnato, JA. 2007. Arch Toxicol. 81: 841-8. PMID: 17680234
  6. Amended safety assessment of sodium picramate and picramic acid.  |  Becker, LC., et al. 2009. Int J Toxicol. 28: 205S-16S. PMID: 20086193
  7. Effect of glucose upon alkaline picrate: a Jaffé interference.  |  Viraraghavan, S. and Blass, KG. 1990. J Clin Chem Clin Biochem. 28: 95-105. PMID: 2329319
  8. [Analysis of picric acid and picramic acid in water samples by ultra performance hydrophilic interaction chromatography-tandem mass spectrometry].  |  Qian, F., et al. 2014. Se Pu. 32: 535-8. PMID: 25185316
  9. Detection of picramic acid and picramate in henné products by NMR Spectroscopy.  |  Nicoletti, M., et al. 2019. Nat Prod Res. 33: 2073-2078. PMID: 29932742
  10. An optimized protocol for estimating cellulase activity in biological samples.  |  Al Talebi, ZA., et al. 2022. Anal Biochem. 655: 114860. PMID: 35985481
  11. Bioconcentration and metabolism of picric acid (2,4,6-trinitrophenol) and picramic acid (2-amino-4,6-dinitrophenol) in rainbow trout Salmo gairdneri.  |  Cooper, KR., et al. 1984. J Toxicol Environ Health. 14: 731-47. PMID: 6520884

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Picramic Acid, 25 g

sc-485013
25 g
$179.00