PIAS 1/3 Antibody (F-3): sc-271172
- PIAS 1/3 Antibody (F-3) is a mouse monoclonal IgG1 κ PIAS 1/3 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 14-43 near the N-terminus of PIAS 1 of human origin
- PIAS 1/3 Antibody (F-3) is recommended for detection of PIAS 1 and PIAS 3 of mouse, rat, human and origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine, porcine and avian
- Anti-PIAS 1/3 Antibody (F-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for PIAS 1/3 Antibody (F-3) for WB applications. This reagent is now offered in a bundle with PIAS 1/3 Antibody (F-3) (see ordering information below).
PIAS 1/3 Antibody (F-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects PIAS 1/3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). PIAS 1/3 (F-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PIAS 1/3 proteins play a crucial role in regulating signal transduction pathways mediated by the IL-6-type family of cytokines, which are essential for gene activation, cell proliferation, and differentiation. Specifically, PIAS 1 acts as a negative regulator of signal transducer and activator of transcription (STAT) proteins, particularly Stat1 and Stat3, by binding to them and inhibiting their DNA-binding activity, thereby preventing target gene transcription. This interaction helps maintain cellular homeostasis and prevents excessive inflammatory responses, which can lead to various diseases. Additionally, PIAS 1/3 proteins are involved in post-translational modifications, such as SUMOylation, which further modulates target protein activity and stability, highlighting their importance in cellular signaling and function.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PIAS 1/3 Antibody (F-3) | sc-271172 | 200 µg/ml | $322.00 | |||
PIAS 1/3 Antibody (F-3): m-IgG Fc BP-HRP Bundle | sc-525791 | 200 µg Ab; 10 µg BP | $361.00 | |||
PIAS 1/3 Antibody (F-3) AC | sc-271172 AC | 500 µg/ml, 25% agarose | $424.00 | |||
PIAS 1/3 Antibody (F-3) HRP | sc-271172 HRP | 200 µg/ml | $322.00 | |||
PIAS 1/3 Antibody (F-3) FITC | sc-271172 FITC | 200 µg/ml | $336.00 | |||
PIAS 1/3 Antibody (F-3) PE | sc-271172 PE | 200 µg/ml | $349.00 | |||
PIAS 1/3 Antibody (F-3) Alexa Fluor® 488 | sc-271172 AF488 | 200 µg/ml | $364.00 | |||
PIAS 1/3 Antibody (F-3) Alexa Fluor® 546 | sc-271172 AF546 | 200 µg/ml | $364.00 | |||
PIAS 1/3 Antibody (F-3) Alexa Fluor® 594 | sc-271172 AF594 | 200 µg/ml | $364.00 | |||
PIAS 1/3 Antibody (F-3) Alexa Fluor® 647 | sc-271172 AF647 | 200 µg/ml | $364.00 | |||
PIAS 1/3 Antibody (F-3) Alexa Fluor® 680 | sc-271172 AF680 | 200 µg/ml | $364.00 | |||
PIAS 1/3 Antibody (F-3) Alexa Fluor® 790 | sc-271172 AF790 | 200 µg/ml | $364.00 | |||
PIAS 1/3 (F-3) Neutralizing Peptide | sc-271172 P | 100 µg/0.5 ml | $69.00 |