PI 3-Kα Inhibitor VIII (CAS 372196-77-5)
Application:
PI 3-Kα Inhibitor VIII is a potent PI 3-kinase inhibitor
CAS Number:
372196-77-5
Molecular Weight:
524.8
Molecular Formula:
C16H14N5O4SBr•HCl•2H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
PI 3-Kα Inhibitor VIII is a cell-permeable imidazopyridine compound that acts as a highly potent and ATP-competitive DNA-PK and p110α-selective PI3-K inhibitor (IC50 = 0.3, 40, 100, and 850 nM for p110α, p110γ, PI 3-K C2β, and p110β, respectively). PI 3-Kα Inhibitor VIII has been shown to effectively block cellular PI3-K/Akt signaling and inhibit tumor growth both in vitro (IC50 ≤58 nM in MCF7, MCF7 ADR-res, HeLa, A375, and A549 cultures) and in mice in vivo (62% inhibition of HeLa xenograft in 2 weeks, 50 mg/kg/day, i.p.).
Inhibitor of:
PI 3-kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PI 3-Kα Inhibitor VIII, 5 mg | sc-364583 | 5 mg | $440.00 |