Molecular structure of Physostigmine salicylate, CAS Number: 57-64-7
Physostigmine salicylate (CAS 57-64-7)
See product citations (1)
Alternate Names:
Eserine salicylate salt
Application:
Physostigmine salicylate is an analogue of Physostigmine
CAS Number:
57-64-7
Molecular Weight:
413.47
Molecular Formula:
C15H21N3O2•C7H6O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Physostigmine salicylate is a derivative of Physostigmine (sc-202764). Physostigmine is an alkaloid originally derived from the Calabar bean (Physostigma venenosum) and noted to act as a potent and reversible inhibitor of cholinesterase. Physostigmine is also reported to form a slowly degrading carbamylated enzyme complex with acetylcholinesterase (AChE). This compound has been used as a positive control in a study investigating acetylcholinesterase inhibitors for potential antihelminthic drug targets. Additionally, this parasympathomimetic compound is reported to cross the blood-brain barrier.
Physostigmine salicylate (CAS 57-64-7) References
- In vitro release and intestinal absorption of physostigmine salicylate from submicron emulsions. | Rubinstein, A., et al. 1991. J Pharm Sci. 80: 643-7. PMID: 1941560
- Effects of subcutaneous and intracerebroventricular injection of physostigmine on the acute corneal nociception in rats. | Tamaddonfard, E. and Hamzeh-Gooshchi, N. 2010. Pharmacol Rep. 62: 858-63. PMID: 21098868
- Cholinergic modulation of narcoleptic attacks in double orexin receptor knockout mice. | Kalogiannis, M., et al. 2011. PLoS One. 6: e18697. PMID: 21533254
- Anticholinesterasic, nematostatic and anthelmintic activities of pyridinic and pyrazinic compounds. | Valli, M., et al. 2011. Curr Med Chem. 18: 3423-30. PMID: 21728957
- Toxicity study of continuous administration of physostigmine salicylate. | Lim, DK., et al. 1988. Pharmacol Biochem Behav. 31: 627-31. PMID: 3251246
- An acetylcholine-dopamine interaction in the nucleus accumbens and its involvement in ethanol's dopamine-releasing effect. | Loftén, A., et al. 2021. Addict Biol. 26: e12959. PMID: 32789970
- The effects of autoclaving on the stability of physostigmine salicylate in buffer solutions. | Yang, ST. and Wilken, LO. 1988. J Parenter Sci Technol. 42: 62-7. PMID: 3385544
- Multiple cholinesterase inhibitors have antidepressant-like properties in the mouse forced swim test. | Fitzgerald, PJ., et al. 2021. Behav Brain Res. 409: 113323. PMID: 33910028
- Rosinidin Protects Streptozotocin-Induced Memory Impairment-Activated Neurotoxicity by Suppressing Oxidative Stress and Inflammatory Mediators in Rats. | Alharbi, KS., et al. 2022. Medicina (Kaunas). 58: PMID: 35893108
- Neuroprotective Efficacy of Europinidin in Streptozotocin-Induced Memory Impairment by Modulation of Oxidative Stress, Inflammatory Mediators, and Cholinesterase Activity in Rats. | Ahmad, A. 2023. Oxid Med Cell Longev. 2023: 5248127. PMID: 36760351
- Structural Insights into the Marine Alkaloid Discorhabdin G as a Scaffold towards New Acetylcholinesterase Inhibitors. | Defant, A., et al. 2024. Mar Drugs. 22: PMID: 38667790
- Liquid chromatographic analysis of physostigmine salicylate and its degradation products. | Rubnov, S., et al. 1999. J Pharm Biomed Anal. 18: 939-45. PMID: 9925328
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Physostigmine salicylate, 25 mg | sc-252784 | 25 mg | $618.00 |