Physcion CAS: 521-61-9
MF: C16H12O5
MW: 284.26
An anthraquinone originally isolated from Rheum emodi.

Physcion (CAS 521-61-9)

Physcion | CAS 521-61-9 is rated 5.0 out of 5 by 1.
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Alternate Names: 1,8-Dihydroxy-3-methoxy-6-methylanthraquinone, Emodin-3-methyl ether
Application: Physcion is an anthraquinone originally isolated from Rheum emodi
CAS Number: 521-61-9
Purity: ≥98%
Molecular Weight: 284.26
Molecular Formula: C16H12O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Physcion is an anthraquinone isolated from Rheum emodi. Has antitumor and antifungal activity.


References

1. Kuo, Y.C., et al. 1997. Life Sci. 61: 2335-2344. PMID: 9408056
2. Agarwal, S.K., et al. 2000. J. Ethanopharmacol. 72: 43-46. PMID: 10967452

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (immiscible), Hexane, methylene chloride, and chloroform.
Storage :
Store at room temperature
Melting Point :
202-204° C (dec.)
Boiling Point :
560.53° C at 760 mmHg (Predicted)
Density :
1.45 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
Neutrophil Elastase: IC50 = 6.2 µM (human); HCT-116: IC50 = 19 µM (human); HepG2: IC50 = 77.3 µM (human); TrxR2: IC50 = 132 µM (rat); Human rhinovirus A protease: IC50 = >150 µM (human rhinovirus sp.)
Ki Data :
P2Y12: Ki= >10 µM (human)
pK Values :
pKa: 6.23 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CB6720000
PubChem CID :
10639
MDL Number :
MFCD00017374
EC Number :
208-315-7
Beilstein Registry :
6770499
SMILES :
CC1=CC(=C2C(=C1)C(=O)C3=CC(=CC(=C3C2=O)O)OC)O

Download SDS (MSDS)

Certificate of Analysis

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Physcion (CAS 521-61-9)  Product Citations

See how others have used Physcion (CAS 521-61-9). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 30841449  2019. Biomed. Pharmacother. 111: 1353-1358.

PMID: # 28713273  Zheng, W. et al. 2017. Front Pharmacol. 8: 421.

PMID: # 29340974  Clin Transl Oncol. 1145-1152.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Kuo et al Kuo et al. (PubMed ID 9408056) found that physcion inhibited tumor cell proliferation in K562 cells. -SCBT Publication Review
Date published: 2015-01-24
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