Molecular structure of Phthalylglycyl chloride, CAS Number: 6780-38-7
Phthalylglycyl chloride (CAS 6780-38-7)
Alternate Names:
1,3-Dioxo-2-isoindolineacetyl chloride; Phthalylglycine acid chloride
CAS Number:
6780-38-7
Purity:
96%
Molecular Weight:
223.61
Molecular Formula:
C10H6ClNO3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Phthalylglycyl chloride as a reagent for the synthesis of peptides and proteins in biochemistry. It is used as a coupling agent in the process of peptide bond formation, where it reacts with amino acids to form peptide bonds. Phthalylglycyl chloride is used as a protecting group for amino acids during peptide synthesis. It can be used to temporarily block the reactive functional groups of amino acids, allowing for selective reactions to occur at specific sites. This helps to control the sequence of amino acids in the synthesis of peptides and proteins. The function of phthalylglycyl chloride in biochemistry is to facilitate the synthesis of peptides and proteins by acting as a coupling agent and protecting group for amino acids.
Phthalylglycyl chloride (CAS 6780-38-7) References
- THE NEW ORLEANS MEETING OF THE AMERICAN CHEMICAL SOCIETY. III. | Parsons, CL. 1915. Science. 42: 94-104. PMID: 17748418
- Synthesis and biological evaluation of 1,4-diaryl-2-azetidinones as specific anticancer agents: activation of adenosine monophosphate activated protein kinase and induction of apoptosis. | Tripodi, F., et al. 2012. J Med Chem. 55: 2112-24. PMID: 22329561
- Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists. | Chen, SR., et al. 2017. Eur J Med Chem. 126: 202-217. PMID: 27776274
- Synthesis and biological evaluation of new 3-amino-2-azetidinone derivatives as anti-colorectal cancer agents. | Tripodi, F., et al. 2018. Medchemcomm. 9: 843-852. PMID: 30108973
- Phthalylglycyl Chloride as a Derivatization Agent for UHPLC-MS/MS Determination of Adrenaline, Dopamine and Octopamine in Urine. | Zorina, M., et al. 2023. Molecules. 28: PMID: 37049663
- 17-Aminoacylamido steroid antidepressants. | Flouret, G., et al. 1972. J Med Chem. 15: 1281-3. PMID: 4635975
- Detection and prevention of urethane acylation during solid-phase peptide synthesis by anhydride methods. | Merrifield, RB., et al. 1974. J Org Chem. 39: 660-8. PMID: 4833502
- Synthesis of peptides containing aminophosphonic acids. | Gilmore, WF. and McBride, HA. 1974. J Pharm Sci. 63: 1087-90. PMID: 4854578
- Novel peptidoaminobenzophenones, terminal N-substituted peptidoaminobenzophenones, and N-(acylglycyl)aminobenzophenones as open-ring derivatives of benzodiazepines. | Hirai, K., et al. 1981. J Med Chem. 24: 20-7. PMID: 6110780
- Heterocyclic cation systems. 14. Synthesis of thieno[3,2-e][1,4]diazepine, thiazolo[4,5-e][1,4]diazepine, and s-triazolo[3,4-c]thiazolo[4,5-e][1,4]diazepine derivatives | Kentaro Hirai, Hirohiko Sugimoto, and Teruyuki Ishiba. 1980,. J. Org. Chem. 45, 2,: 253–260.
- A New Approach to the Synthesis of 4-Phosphonylated β-Lactams | Dorota G. Piotrowska*, et al. 2015;. Synlett. 26(03):: 375-379.
- Immobilized boronic acid for Suzuki–Miyaura coupling: application to the generation of pharmacologically relevant molecules† | M. Martinez-Amezaga, C. M. L. Delpiccolo and E. G. MataORCID logo*. 2017,. RSC Adv.,. 7,: 34994-35003.
- Photo-induced synthesis and in vitro biological activity of a Sansalvamide A analog | L Zhao, H Zhang, G Tan, Z Wang, Y Jin - Tetrahedron Letters, 2017 - Elsevier. 19 April 2017,. Tetrahedron Letters. Volume 58, Issue 16,: Pages 1669-1672.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Phthalylglycyl chloride, 1 g | sc-236395 | 1 g | $265.00 |