Date published: 2026-4-4

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Phthalic anhydride (CAS 85-44-9)

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Application:
Phthalic anhydride is an intermediate in chemical synthesis and plastics manufacturing
CAS Number:
85-44-9
Purity:
≥99%
Molecular Weight:
148.12
Molecular Formula:
C8H4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Phthalic anhydride, with the chemical formula C6H4(CO)2O, is an organic compound derived from phthalic acid by removing water (dehydration). This white crystalline solid is highly reactive and serves as an important industrial chemical, primarily used as a precursor in the production of plasticizers, dyes, and pigments. The reactivity of phthalic anhydride primarily stems from its anhydride functional group, which readily reacts with alcohols and amines to form esters and amides, respectively. This ability to form diverse chemical bonds underlies its widespread use in synthesizing a variety of important industrial compounds. In research contexts, phthalic anhydride is utilized to study these reaction mechanisms, particularly in the context of polyester synthesis where it reacts with glycols to form polyesters, a process crucial for producing resins and fibers. Additionally, the behavior of phthalic anhydride under various environmental conditions is of interest in atmospheric chemistry, where it can be a product of complex photochemical reactions involving anthropogenic pollutants. Researchers also explore its potential as a building block in organic synthesis, creating novel organic molecules that could have applications in materials science, especially in developing new polymers with specific desired properties such as enhanced durability or thermal stability.


Phthalic anhydride (CAS 85-44-9) References

  1. Phthalic anhydride-induced skin inflammation is augmented in KLF10-deficient mice.  |  Bae, CJ., et al. 2013. J Dermatol Sci. 71: 221-4. PMID: 23707674
  2. Phthalic anhydride: Illustrating a conundrum in chemical allergy.  |  Basketter, DA. and Kimber, I. 2016. J Immunotoxicol. 13: 767-769. PMID: 27230707
  3. Phthalic anhydride esterified chicha gum: characterization and antibacterial activity.  |  Silva, SCCC., et al. 2021. Carbohydr Polym. 251: 117077. PMID: 33142620
  4. Safety Assessment of Trimellitic Anhydride Copolymers as Used in Cosmetics.  |  Fiume, MM., et al. 2020. Int J Toxicol. 39: 74S-92S. PMID: 33203270
  5. Copolymerization of Phthalic Anhydride with Epoxides Catalyzed by Amine-Bis(Phenolate) Chromium(III) Complexes.  |  Bukowski, W., et al. 2021. Polymers (Basel). 13: PMID: 34071682
  6. Pressure-induced Fermi resonance between fundamental modes in phthalic anhydride.  |  Liu, H., et al. 2022. J Phys Condens Matter. 34: PMID: 35193125
  7. Composition, Properties, and Utilization of Fumaric Acid Sludge By-Produced from Industrial Phthalic Anhydride Wastewater Treatment.  |  Wei, Z., et al. 2022. Polymers (Basel). 14: PMID: 36501563
  8. Phthalic anhydride (PA): a valuable substrate in organic transformations.  |  Nikoofar, K. and Sadathosainy, M. 2023. RSC Adv. 13: 23870-23946. PMID: 37588043
  9. Phthalic anhydride-induced occupational asthma.  |  Wernfors, M., et al. 1986. Int Arch Allergy Appl Immunol. 79: 77-82. PMID: 3941014

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Phthalic anhydride, 25 g

sc-203189
25 g
$34.00

Phthalic anhydride, 500 g

sc-203189A
500 g
$83.00

Phthalic anhydride, 2.5 kg

sc-203189B
2.5 kg
$248.00