Date published: 2025-10-20

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Phthalic acid (CAS 88-99-3)

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Alternate Names:
1,2-benzenedicarboxylic acid
Application:
Phthalic acid is an ortho-carboxylic acid benzoic acid derivative
CAS Number:
88-99-3
Molecular Weight:
166.13
Molecular Formula:
C8H6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Phthalic acid, denoted chemically as C6H4(CO2H)2, is an aromatic dicarboxylic acid characterized by the presence of two carboxyl groups attached to a benzene ring. This white, crystalline solid is primarily used in the chemical industry as a precursor to phthalate esters, which are used extensively in the manufacture of synthetic resins and other polymers. However, phthalic acid itself holds significant interest in various research fields due to its structural and chemical properties. One of the key mechanisms of phthalic acid involves its role in the synthesis of polyesters and alkyd resins, where it reacts with alcohols and polyols to form ester linkages, a process that is fundamental to producing materials with desired durability and flexibility characteristics. In analytical chemistry, phthalic acid is often utilized as a standard for calibrating instruments that measure organic substances due to its well-defined crystalline structure and stability. Additionally, its acid dissociation constants (pKa values) are of particular interest in studies of acid-base chemistry, where phthalic acid serves as a model compound to explore the behavior of dicarboxylic acids. Researchers also explore its potential in creating biodegradable plastics and environmentally friendly polymers, aiming to leverage its reactivity to synthesize materials with lower environmental impact compared to traditional petrochemical-derived plastics.


Phthalic acid (CAS 88-99-3) References

  1. Phthalic acid mimics 17beta-estradiol actions in WISH cells.  |  Pavan, B., et al. 2001. Toxicol Lett. 118: 157-64. PMID: 11137322
  2. Elucidation of the toxic mechanism of the plasticizers, phthalic acid esters, putative endocrine disrupters: effects of dietary di(2-ethylhexyl)phthalate on the metabolism of tryptophan to niacin in rats.  |  Fukuwatari, T., et al. 2002. Biosci Biotechnol Biochem. 66: 705-10. PMID: 12036039
  3. Phthalic acid chemical probes synthesized for protein-protein interaction analysis.  |  Liang, SS., et al. 2013. Int J Mol Sci. 14: 12914-30. PMID: 23797655
  4. Toxicological characterization of phthalic Acid.  |  Bang, du Y., et al. 2011. Toxicol Res. 27: 191-203. PMID: 24278572
  5. Engineering Transcription Factor XylS for Sensing Phthalic Acid and Terephthalic Acid: An Application for Enzyme Evolution.  |  Li, J., et al. 2022. ACS Synth Biol. 11: 1106-1113. PMID: 35192317
  6. Responses of transcriptome and metabolome in the roots of Pugionium cornutum (L.) Gaertn to exogenously applied phthalic acid.  |  Zhang, X., et al. 2022. BMC Plant Biol. 22: 535. PMID: 36396992
  7. Biodegradation of diethyl phthalate and phthalic acid by a new indigenous Pseudomonas putida.  |  Shariati, S., et al. 2023. Folia Microbiol (Praha). 68: 477-488. PMID: 36635520
  8. Biodegradation of phthalic acid and terephthalic acid by Comamonas testosteroni strains.  |  Vural, C. and Ettadili, H. 2024. Folia Microbiol (Praha).. PMID: 38809402
  9. Biological effects of di-(2-ethylhexyl) phthalate and other phthalic acid esters.  |  Thomas, JA. and Thomas, MJ. 1984. Crit Rev Toxicol. 13: 283-317. PMID: 6386344
  10. Overview of phthalate ester pharmacokinetics in mammalian species.  |  Kluwe, WM. 1982. Environ Health Perspect. 45: 3-9. PMID: 6754362

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Phthalic acid, 25 g

sc-203188
25 g
$40.00

Phthalic acid, 250 g

sc-203188A
250 g
$80.00

Phthalic acid, 1 kg

sc-203188B
1 kg
$125.00