Date published: 2025-9-13

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Phosphotungstic acid (CAS 12501-23-4)

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Alternate Names:
Tungstophosphoric acid
Application:
Phosphotungstic acid is a useful histology stain for cell specimens
CAS Number:
12501-23-4
Molecular Weight:
2880.05
Molecular Formula:
12WO3•H3PO4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Phosphotungstic acid is a white, crystalline solid classified as a phosphotungstate compound. Its reaction mechanism involves the formation of an acid complex through protonation by water. This can be represented by the equation: PW6O14(OH)2 + H2O → PW6O14(OH)3H+ + OH-. The resulting solution is highly acidic, typically having a pH of 2 or lower. The hydroxyl groups present in the phosphotungstate compound can react with hydrogen fluoride, leading to the generation of tungsten hexafluoride gas. The structural analysis of phosphotungstic acid relies on the hydrogen bonding interactions between its hydroxyl groups. Furthermore, this compound can serve as an oxidation catalyst when combined with substances like magnesium salt.


Phosphotungstic acid (CAS 12501-23-4) References

  1. Chemotherapy of cancer with phosphotungstic acid-H2O2 and phosphomolybdic acid-H2O2 preparations.  |  MUKHERJEE, HN. 1950. J Indian Med Assoc. 19: 277-9. PMID: 15428640
  2. [Analytical application of phosphotungstic acid complexes. Synthesis and characterisation].  |  Apostu, M., et al. 2007. Rev Med Chir Soc Med Nat Iasi. 111: 530-4. PMID: 17983198
  3. Phosphotungstic acid: an efficient, cost-effective and recyclable catalyst for the synthesis of polysubstituted quinolines.  |  Dabiri, M. and Bashiribod, S. 2009. Molecules. 14: 1126-44. PMID: 19305365
  4. Phosphotungstic acid encapsulated in metal-organic framework as catalysts for carbohydrate dehydration to 5-hydroxymethylfurfural.  |  Zhang, Y., et al. 2011. ChemSusChem. 4: 59-64. PMID: 21226212
  5. Isolation of cellulose from rice straw and its conversion into cellulose acetate catalyzed by phosphotungstic acid.  |  Fan, G., et al. 2013. Carbohydr Polym. 94: 71-6. PMID: 23544511
  6. Pyronin-phosphotungstic acid: spectral characteristics and staining pattern on Epon semithin sections.  |  Armas-Portela, R. and Stockert, JC. 1986. Acta Histochem. 79: 205-9. PMID: 2428197
  7. Direct determination of creatinine based on poly(ethyleneimine)/phosphotungstic acid multilayer modified electrode.  |  Han, P., et al. 2016. Talanta. 151: 114-118. PMID: 26946017
  8. Preparation and characterization of microcrystalline cellulose from waste cotton fabrics by using phosphotungstic acid.  |  Hou, W., et al. 2019. Int J Biol Macromol. 123: 363-368. PMID: 30445076
  9. Anchoring Water Soluble Phosphotungstic Acid by Hybrid Fillers to Construct Three-Dimensional Proton Transport Networks.  |  He, S., et al. 2021. Membranes (Basel). 11: PMID: 34357185
  10. Phosphotungstic acid as a novel acidic catalyst for carbohydrate protection and glycosylation.  |  Chen, JS., et al. 2019. RSC Adv. 9: 33853-33862. PMID: 35528919
  11. The reactivity and staining of tissue proteins with phosphotungstic acid.  |  Silverman, L. and Glick, D. 1969. J Cell Biol. 40: 761-7. PMID: 4179634
  12. Re-examination of effect of paracetamol on serum uric acid measured by phosphotungstic acid reduction.  |  Smith, M. and Payne, RB. 1979. Ann Clin Biochem. 16: 96-9. PMID: 464539
  13. A one-tube serum uric acid method using phosphotungstic acid as protein precipitant and color reagents.  |  Pileggi, VJ., et al. 1972. Clin Chim Acta. 37: 141-9. PMID: 5022076
  14. On the mechanism of Mallory's phosphotungstic acid-haematoxylin stain.  |  Puchtler, H., et al. 1980. J Microsc. 119: 383-90. PMID: 6157822

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Phosphotungstic acid, 10 g

sc-215716
10 g
$61.00

Phosphotungstic acid, 25 g

sc-215716A
25 g
$82.00