Phosphodiesterase 4 Inhibitor is a pyrazole compound with a high-affinity active site binding inhibitor of PDE4B (phosphodiesterase IVB) and PDE4D (phosphodiesterase IVD) (IC50 = 33 nM and 21 nM). More potent than Rolipram (IC50 = 570 nM and 1.1 μM for PDEIVB and PDEIVD), respectively and greater selectivity over PDEIB, PDEIIA, PDEIIIB, PDEVA, PDEVIIB, PDEVIIIA, PDEIXA and PDEXIA (IC50 > 30 μM) and minimally inhibit PDEXA with an IC50 of 6.9 μM.
Card, G.L., et al. 2005. Nat. Biotech. 23 , 201. Card, G.L., et al. 2004. Structure 12, 2233.
Soluble in methanol (5 mg/ml), and DMSO (10 mg/ml).
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