Phosphodiesterase 4 Inhibitor CAS: 346440-86-6
MF: C14H15N3O4
MW: 289.3
A pyrazole compound with an active site binding inhibitor of phosphodiester.

Phosphodiesterase 4 Inhibitor (CAS 346440-86-6)

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Application: Phosphodiesterase 4 Inhibitor is a pyrazole compound with an active site binding inhibitor of phosphodiester
CAS Number: 346440-86-6
Purity: ≥97%
Molecular Weight: 289.3
Molecular Formula: C14H15N3O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Phosphodiesterase 4 Inhibitor is a pyrazole compound with a high-affinity active site binding inhibitor of PDE4B (phosphodiesterase IVB) and PDE4D (phosphodiesterase IVD) (IC50 = 33 nM and 21 nM). More potent than Rolipram (IC50 = 570 nM and 1.1 μM for PDEIVB and PDEIVD), respectively and greater selectivity over PDEIB, PDEIIA, PDEIIIB, PDEVA, PDEVIIB, PDEVIIIA, PDEIXA and PDEXIA (IC50 > 30 μM) and minimally inhibit PDEXA with an IC50 of 6.9 μM.


References

Card, G.L., et al. 2005. Nat. Biotech. 23 , 201. Card, G.L., et al. 2004. Structure 12, 2233.

Physical State :
Solid
Solubility :
Soluble in methanol (5 mg/ml), and DMSO (10 mg/ml).
Storage :
Store at 4° C
Melting Point :
172.28° C (Predicted)
Boiling Point :
411.77° C at 760 mmHg (Predicted)
Density :
1.30 g/cm3 (Predicted)
Refractive Index :
n20D 1.6 (Predicted)
IC50 :
PDE IV B: IC50 = 33 nM; PDE IV D: IC50 = 21 nM; PDEXA: IC50 = 6.9 µM; PDEIB, PDEIIA, PDEIIIB, PDEVA, PDEVIIB, PDEVIIIA, PDEIXA and PDEXIA: IC50 = >30 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
656969
MDL Number :
MFCD09037551
SMILES :
CCOC(=O)C1=C(N(N=C1C)C2=CC(=CC=C2)[N+](=O)[O-])C

Download SDS (MSDS)

Certificate of Analysis

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