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Phosphocreatine di(tris) salt (CAS 108321-17-1)

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Alternate Names:
Creatine phosphate di(tris) salt; N-(Imino[phosphonoamino]methyl)-N-methylglycine
Application:
Phosphocreatine di(tris) salt is a product used in systems where alkali metal ions are undesirable
CAS Number:
108321-17-1
Purity:
≥97%
Molecular Weight:
453.38
Molecular Formula:
C12H32N5O11P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Phosphocreatine di(tris) salt (PCr) provides phosphate for ADP-ATP conversion. It is a high-energy phosphate reservoir in vertebrate and some invertebrate muscle, protecting against anoxic and ischemic damage to brain neurons. Phosphocreatine di(tris) salt has been studied for its potential to modulate cellular energy metabolism, as well as its potential to act as an antioxidant and protect cells from oxidative stress. In addition, it has been studied for its potential to regulate gene expression and be used as a marker for cell death.


Phosphocreatine di(tris) salt (CAS 108321-17-1) References

  1. Escherichia coli uracil- and ethenocytosine-initiated base excision DNA repair: rate-limiting step and patch size distribution.  |  Sung, JS. and Mosbaugh, DW. 2003. Biochemistry. 42: 4613-25. PMID: 12705824
  2. Drs2p-coupled aminophospholipid translocase activity in yeast Golgi membranes and relationship to in vivo function.  |  Natarajan, P., et al. 2004. Proc Natl Acad Sci U S A. 101: 10614-9. PMID: 15249668
  3. Evidence that a Chloroplast Surface Protein Is Associated with a Specific Binding Site for the Precursor to the Small Subunit of Ribulose-1,5-Bisphosphate Carboxylase.  |  Cornwell, KL. and Keegstra, K. 1987. Plant Physiol. 85: 780-5. PMID: 16665776
  4. Peptide neurotransmitters activate a cation channel complex of NALCN and UNC-80.  |  Lu, B., et al. 2009. Nature. 457: 741-4. PMID: 19092807
  5. Potentiating effect of eszopiclone on GABA(A) receptor-mediated responses in pedunculopontine neurons.  |  Ye, M. and Garcia-Rill, E. 2009. Sleep. 32: 879-87. PMID: 19639750
  6. Local control of postinhibitory rebound spiking in CA1 pyramidal neuron dendrites.  |  Ascoli, GA., et al. 2010. J Neurosci. 30: 6434-42. PMID: 20445069
  7. Cannabinoid receptor-mediated regulation of neuronal activity and signaling in glomeruli of the main olfactory bulb.  |  Wang, ZJ., et al. 2012. J Neurosci. 32: 8475-9. PMID: 22723687
  8. Short-term depression of external globus pallidus-subthalamic nucleus synaptic transmission and implications for patterning subthalamic activity.  |  Atherton, JF., et al. 2013. J Neurosci. 33: 7130-44. PMID: 23616523
  9. Activation of group I metabotropic glutamate receptors enhances persistent sodium current and rhythmic bursting in main olfactory bulb external tufted cells.  |  Dong, HW. and Ennis, M. 2014. J Neurophysiol. 111: 641-7. PMID: 24225539
  10. Identification of both GABAA receptors and voltage-activated Na(+) channels as molecular targets of anticonvulsant α-asarone.  |  Wang, ZJ., et al. 2014. Front Pharmacol. 5: 40. PMID: 24653701
  11. Altered enzyme activities and citrulline synthesis in liver mitochondria from ornithine carbamoyltransferase-deficient sparse-furash mice.  |  Cohen, NS., et al. 1989. Biochem J. 257: 251-7. PMID: 2920015
  12. Activation of Group II Metabotropic Glutamate Receptors Suppresses Excitability of Mouse Main Olfactory Bulb External Tufted and Mitral Cells.  |  Dong, HW. and Ennis, M. 2017. Front Cell Neurosci. 11: 436. PMID: 29386998
  13. Modulation of cardiac Na+ channels expressed in a mammalian cell line and in ventricular myocytes by protein kinase C.  |  Qu, Y., et al. 1994. Proc Natl Acad Sci U S A. 91: 3289-93. PMID: 8159741
  14. Amantadine inhibits nicotinic acetylcholine receptor function in hippocampal neurons.  |  Matsubayashi, H., et al. 1997. J Pharmacol Exp Ther. 281: 834-44. PMID: 9152392
  15. Strychnine: a potent competitive antagonist of alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal neurons.  |  Matsubayashi, H., et al. 1998. J Pharmacol Exp Ther. 284: 904-13. PMID: 9495848

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Phosphocreatine di(tris) salt, 500 mg

sc-212557
500 mg
$135.00

Phosphocreatine di(tris) salt, 1 g

sc-212557A
1 g
$215.00

Phosphocreatine di(tris) salt, 5 g

sc-212557B
5 g
$852.00

Hello I was wondering if you have this salt ready to ship.

Asked by: Martin Sisti
Thank you for contacting Santa Cruz Biotechnology. Please email tech service for a price quote and ship date . Please email scbt@scbt.com
Answered by: BlakeJ
Date published: 2024-07-25

What is the osmole for a 1 mole creatine phosphate di(tris) salt? Thanks

Asked by: Sol2
Thank you for your question. It would be helpful if you could call us directly at 800-457-3801 ext 1, allowing for a more interactive discussion of this and other related questions.
Answered by: Blake J
Date published: 2021-08-11
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Rated 5 out of 5 by from AhsanAhsan, A. et al. (PubMed 26404526) reported that Phosphocreatine protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway. -SCBT Publication Review
Date published: 2015-06-07
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Phosphocreatine di(tris) salt is rated 5.0 out of 5 by 1.
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