Date published: 2026-5-12

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Phosphazene base P1-t-Bu (CAS 81675-81-2)

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Alternate Names:
tert-Butylimino-tris(dimethylamino)phosphorane
CAS Number:
81675-81-2
Purity:
≥97%
Molecular Weight:
234.32
Molecular Formula:
C10H27N4P
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Phosphazene base P1-t-Bu is a strong non-metallic organophosphorus base that is widely used in synthetic organic chemistry research. It is particularly valued for its role in deprotonation reactions where it acts as a potent base, capable of generating carbanions from a variety of proton-containing compounds, including active hydrogen compounds like alcohols, phenols, and carboxylic acids. Researchers leverage Phosphazene base P1-t-Bu in studying the kinetics and mechanisms of various base-catalyzed reactions, due to its high basicity and the relatively non-nucleophilic nature of the phosphazene group. This compound is also used in the synthesis of fine chemicals where precise control over pH-sensitive steps is required. Furthermore, Phosphazene base P1-t-Bu finds application in polymer chemistry, where it facilitates anionic polymerization processes, enabling the production of polymers with specific molecular weight distributions and architectures.


Phosphazene base P1-t-Bu (CAS 81675-81-2) References

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  8. An Investigation of the Organoborane/Lewis Base Pairs on the Copolymerization of Propylene Oxide with Succinic Anhydride.  |  Hu, LF., et al. 2020. Molecules. 25: PMID: 31936276
  9. Highly Efficient Darzens Reactions Mediated by Phosphazene Bases under Mild Conditions.  |  Lops, C., et al. 2022. ChemistryOpen. 11: e202200179. PMID: 36207800
  10. Control over Dethreading Kinetics Allows Evaluating the Entropy Stored in an Interlocked Molecular Machine Out-of-Equilibrium.  |  Di Noja, S., et al. 2023. Chemistry. e202300295. PMID: 36795861
  11. A solid phase traceless synthesis of 2-arylaminobenzimidazoles  |  Krchňák, V., Smith, J., & Vágner, J. 2001. Tetrahedron Letters. 42(9): 1627-1630.
  12. Traces do matter-Purity of 4-methyl-2-oxetanone and its effect on anionic ring-opening polymerization as evidenced by phosphazene superbase catalysis  |  Kawalec, M., Coulembier, O., Gerbaux, P., Sobota, M., De Winter, J., Dubois, P.,.. & Kurcok, P. 2012. Reactive and Functional Polymers. 72(8): 509-520.
  13. Use of Phosphazene Base BTPP for Phosphorylative Activation in the Scale-Up of BET Inhibitor GSK525762  |  Jones, R. E., Aspin, P., Davies, S. H., Mann, I., Priestley, C., Roberts, A. D.,.. & Leahy, J. H. 2022. Organic Process Research & Development. 26(9): 2646-2655.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Phosphazene base P1-t-Bu, 5 ml

sc-253268
5 ml
$401.00