Molecular structure of Phosphatidylinositol, CAS Number: 383907-36-6
Phosphatidylinositol (CAS 383907-36-6)
CAS Number:
383907-36-6
Purity:
≥98%
Molecular Weight:
881
Molecular Formula:
C45H78O13P•Na
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Phosphatidylinositol (PI) is a phospholipid present in the cell membranes of eukaryotic cells, including those in plants. Comprised of a glycerol backbone, two fatty acid chains, and a phosphate group attached to the hydroxyl group of the inositol ring, Phosphatidylinositol plays a significant role in various cellular processes. These include signal transduction, cell growth, and cell division. Notably, in the context of plant, wheat germ (Na+ salt), Phosphatidylinositol plays a vital role in regulating cell growth and development. Its involvement extends to the regulation of cell cycle progression, cell differentiation, and cell death. Additionally, Phosphatidylinositol influences signal transduction and gene expression regulation.
Phosphatidylinositol (CAS 383907-36-6) References
- Identification of AtPIS, a phosphatidylinositol synthase from Arabidopsis. | Collin, S., et al. 1999. Eur J Biochem. 262: 652-8. PMID: 10411624
- Surfactant protein A regulates pulmonary surfactant secretion via activation of phosphatidylinositol 3-kinase in type II alveolar cells. | White, MK. and Strayer, DS. 2000. Exp Cell Res. 255: 67-76. PMID: 10666335
- Phosphatidylinositol is an essential phospholipid of mycobacteria. | Jackson, M., et al. 2000. J Biol Chem. 275: 30092-9. PMID: 10889206
- A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3'-kinase activation and endothelial cell migration. | Gille, H., et al. 2000. EMBO J. 19: 4064-73. PMID: 10921887
- Nucleophosmin-anaplastic lymphoma kinase associated with anaplastic large-cell lymphoma activates the phosphatidylinositol 3-kinase/Akt antiapoptotic signaling pathway. | Bai, RY., et al. 2000. Blood. 96: 4319-27. PMID: 11110708
- Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. | Waltner-Law, ME., et al. 2002. J Biol Chem. 277: 34933-40. PMID: 12118006
- M-CSF stimulated differentiation requires persistent MEK activity and MAPK phosphorylation independent of Grb2-Sos association and phosphatidylinositol 3-kinase activity. | Gobert Gosse, S., et al. 2005. Cell Signal. 17: 1352-62. PMID: 16125055
- Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2. | Wilkes, MC., et al. 2005. Cancer Res. 65: 10431-40. PMID: 16288034
- Safety Assessment of Lecithin and Other Phosphoglycerides as Used in Cosmetics. | Johnson, W., et al. 2020. Int J Toxicol. 39: 5S-25S. PMID: 32975152
- Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase. | Pleiman, CM., et al. 1993. Mol Cell Biol. 13: 5877-87. PMID: 8395016
- Differential association of phosphatidylinositol 3-kinase with insulin receptor substrate (IRS)-1 and IRS-2 in human thymocytes in response to IL-7. | Sharfe, N. and Roifman, CM. 1997. J Immunol. 159: 1107-14. PMID: 9233603
- Role of phosphatidylinositol 3-kinase activation in the hypertrophic growth of adult ventricular cardiomyocytes. | Schlüter, KD., et al. 1998. Cardiovasc Res. 40: 174-81. PMID: 9876330
- Inhibitory action of phosphatidylinositol on synaptosomal (Na++K+)-ATPase activity | T Nishikawa, M Goto, S Shimizu. 1985. Biochemical and Biophysical Research Communications. 126, 2: 893-900.
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| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Phosphatidylinositol, 1 ml | sc-281130 | 1 ml | $581.00 |