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Phosphatidic Acid, Dioleoyl has been shown to activate PKC α, ε, or ζ isotypes in the cytosol of COS cells. This compound not only stimulates PKC-ζ-mediated phosphorylation of distinctive substrates, but additionally causes an upward shift in electrophoretic mobility of PKC &zeta. Furthermore, experiments have reported Phosphatidic Acid to be generated by hydrolysis of phosphatidylcholine, via phospholipase D (PLD). Mechanistic studies suggest activation of PLD by insulin and consequential generation of Phosphatidic Acid which then induces Raf-1 translocation to cell membranes. Raf-1 is an essential component to the mitogen-activated protein kinase cascade, and once it has crossed over to the plasma membrane, other factors may activate it through phosphorylation.
1. Limatola, C., et al. 1994. Biochem. J. 304: 1001-1008. PMID: 7818462
2. Boarder, M.R. 1994. Trends Pharmacol. Sci. 15: 57-62. PMID: 8165726
3. Rizzo, M.A., et al. 1999. J. Biol. Chem. 274: 1131-1139. PMID: 9873061
4. Rizzo, M.A., et al. 2000. J. Biol. Chem. 275: 23911-23918. PMID: 10801816
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