Molecular structure of Phorbol 13-myristate, CAS Number: 115905-51-6
Phorbol 13-myristate (CAS 115905-51-6)
Application:
Phorbol 13-myristate is a 14 carbon fatty acid phorbol derivative
CAS Number:
115905-51-6
Purity:
≥97%
Molecular Weight:
574.8
Molecular Formula:
C34H54O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Phorbol 13-myristate is a potent activator of protein kinase C (PKC), a family of enzymes involved in regulating various cellular functions. It functions by binding to the C1 domain of PKC, leading to its translocation from the cytosol to the cell membrane, where it becomes activated. This activation triggers a cascade of phosphorylation events, ultimately modulating the activity of numerous downstream signaling molecules and transcription factors. By doing so, phorbol 13-myristate plays a role in regulating processes such as cell proliferation, differentiation, and apoptosis. Its mechanism of action involves the activation of PKC, which in turn influences various cellular pathways and gene expression.
Phorbol 13-myristate (CAS 115905-51-6) References
- Differential effects of phorbol-13-monoesters on human immunodeficiency virus reactivation. | Márquez, N., et al. 2008. Biochem Pharmacol. 75: 1370-80. PMID: 18241838
- Phorbol ester inhibition of the hormone-stimulated phosphoinositide cycle in WRK-1 cells. | Monaco, ME. and Mufson, RA. 1986. Biochem J. 236: 171-5. PMID: 3790069
- Regulation of nicotinic acetylcholine receptors on human neuroblastoma cells during differentiation. | Halvorsen, SW., et al. 1995. Biochem Pharmacol. 50: 1665-71. PMID: 7503770
- Differential effects of forskolin and phorbol-13-myristate injected intrathecally or intracerebroventricularly on antinociception induced by morphine or beta-endorphin administered intracerebroventricularly in the mouse. | Suh, HW., et al. 1996. Neuropeptides. 30: 177-85. PMID: 8771560
- Influence of side chains on phorbol ester binding to protein kinase C | and Emily Yeh, Nancy A. Sharkey, Peter M. Blumberg. September 1987. Phytotherapy Research. Volume1, Issue3: Pages 135-139.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Phorbol 13-myristate, 1 mg | sc-361975 | 1 mg | $44.00 | |||
Phorbol 13-myristate, 5 mg | sc-361975A | 5 mg | $204.00 |