Molecular structure of Phorbol 12,13-didecanoate, CAS Number: 24928-17-4
Phorbol 12,13-didecanoate (CAS 24928-17-4)
See product citations (1)
Application:
Phorbol 12,13-didecanoate is a strong NO promoter and potent protein kinase C activator
CAS Number:
24928-17-4
Molecular Weight:
672.9
Molecular Formula:
C40H64O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Phorbol-12,13-didecanoate is a strong NO promoter; potent activator of protein kinase C; promotes iNOS expression in cultured hepatocytes. More potent than phorbol myristate acetate as an inflammatory agent, but weaker as a tumor promoting agent.
Phorbol 12,13-didecanoate (CAS 24928-17-4) References
- PKC modulation of minK current involves multiple phosphorylation sites. | Lo, CF. and Numann, R. 1999. Ann N Y Acad Sci. 868: 431-3. PMID: 10414315
- Hyposmotically induced amino acid release from the rat cerebral cortex: role of phospholipases and protein kinases. | Estevez, AY., et al. 1999. Brain Res. 844: 1-9. PMID: 10536255
- Activation of urothelial transient receptor potential vanilloid 4 by 4alpha-phorbol 12,13-didecanoate contributes to altered bladder reflexes in the rat. | Birder, L., et al. 2007. J Pharmacol Exp Ther. 323: 227-35. PMID: 17636010
- Cardiac fibroblasts have functional TRPV4 activated by 4alpha-phorbol 12,13-didecanoate. | Hatano, N., et al. 2009. Life Sci. 85: 808-14. PMID: 19879881
- [Pathophysiological roles of transient receptor potential channels in glial cells]. | Shirakawa, H., et al. 2010. Yakugaku Zasshi. 130: 281-7. PMID: 20190511
- Functional interaction of TRPV4 channel protein with annexin A2 in DRG. | Ning, L., et al. 2012. Neurol Res. 34: 685-93. PMID: 22762361
- 4α-phorbol 12,13-didecanoate activates cultured mouse dorsal root ganglia neurons independently of TRPV4. | Alexander, R., et al. 2013. Br J Pharmacol. 168: 761-72. PMID: 22928864
- Role of colchicine-induced microtubule depolymerization in hyperalgesia via TRPV4 in rats with chronic compression of the dorsal root ganglion. | Ning, L., et al. 2014. Neurol Res. 36: 70-8. PMID: 24074178
- Activation of TRPM7 channels by small molecules under physiological conditions. | Hofmann, T., et al. 2014. Pflugers Arch. 466: 2177-89. PMID: 24633576
- Prolactin affects bovine oocytes through direct and cumulus-mediated pathways. | Lebedeva, IY., et al. 2014. Theriogenology. 82: 1154-64. PMID: 25212395
- Promoting increased mechanical properties of tissue engineered neocartilage via the application of hyperosmolarity and 4α-phorbol 12,13-didecanoate (4αPDD). | Lee, JK., et al. 2014. J Biomech. 47: 3712-8. PMID: 25442009
- Cross-talk of parathyroid hormone-responsive dual signal transduction systems in osteoblastic osteosarcoma cells: its role in PTH-induced homologous desensitization of intracellular calcium response. | Sugimoto, T., et al. 1994. J Cell Physiol. 158: 374-80. PMID: 8106573
- Adenosine-induced activation of ATP-sensitive K+ channels in excised membrane patches is mediated by PKC. | Hu, K., et al. 1999. Am J Physiol. 276: H488-95. PMID: 9950849
Activator of:
PKC.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Phorbol 12,13-didecanoate, 1 mg | sc-202286 | 1 mg | $68.00 |