Date published: 2026-1-15

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Phorate Oxon (CAS 2600-69-3)

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Alternate Names:
Phosphorothioic Acid O,O-Diethyl S-[(Ethylthio)methyl] Ester
CAS Number:
2600-69-3
Molecular Weight:
244.31
Molecular Formula:
C7H17O3PS2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Phorate Oxon is a toxic metabolite of Phorate, an inhibitor of acetylcholinesterase and pseudocholinesterase. The inhibition of acetylcholinesterase leads to the accumulation of acetylcholine in synaptic junctions, causing continuous stimulation of muscles, glands, and the central nervous system. Phorate itself is used in agriculture to control nematodes, insects, and mites. The term "oxon" refers to the oxidation product of phorate. The conversion of phorate to phorate oxon involves the addition of oxygen to the molecular structure, a transformation that often occurs through environmental processes or metabolic actions within organisms. This transformation is an important aspect of the compound′s behavior in the environment and its interaction with target pests, influencing its effectiveness and persistence in agricultural applications.


Phorate Oxon (CAS 2600-69-3) References

  1. Hypersalinity acclimation increases the toxicity of the insecticide phorate in coho salmon (Oncorhynchus kisutch).  |  Lavado, R., et al. 2011. Environ Sci Technol. 45: 4623-9. PMID: 21488666
  2. Effect of sonication on eliminating of phorate in apple juice.  |  Zhang, Y., et al. 2012. Ultrason Sonochem. 19: 43-8. PMID: 21669544
  3. A comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides.  |  Wilhelm, CM., et al. 2014. Toxicol Appl Pharmacol. 281: 254-65. PMID: 25448441
  4. Assessing the therapeutic efficacy of oxime therapies against percutaneous organophosphorus pesticide and nerve agent challenges in the Hartley guinea pig.  |  Snider, TH., et al. 2015. J Toxicol Sci. 40: 759-75. PMID: 26558457
  5. Toxicity and median effective doses of oxime therapies against percutaneous organophosphorus pesticide and nerve agent challenges in the Hartley guinea pig.  |  Snider, TH., et al. 2016. J Toxicol Sci. 41: 511-21. PMID: 27432237
  6. Dissipation behavior of phorate and its toxic metabolites in the sandy clay loam soil of a tropical sugarcane ecosystem using a single-step sample preparation method and GC-MS.  |  Ramasubramanian, T. and Paramasivam, M. 2016. J Sep Sci. 39: 3973-3982. PMID: 27546010
  7. Acute toxicity of phorate oxon by oral gavage in the Sprague-Dawley rat.  |  Snider, TH., et al. 2016. Fundam Toxicol Sci. 3: 195-204. PMID: 28856079
  8. Evaluating the broad-spectrum efficacy of the acetylcholinesterase oximes reactivators MMB4 DMS, HLö-7 DMS, and 2-PAM Cl against phorate oxon, sarin, and VX in the Hartley guinea pig.  |  Wilhelm, CM., et al. 2018. Neurotoxicology. 68: 142-148. PMID: 30056178
  9. Stereospecificity in the oxidation of phorate and phorate sulphoxide by purified FAD-containing mono-oxygenase and cytochrome P-450 isozymes.  |  Levi, PE. and Hodgson, E. 1988. Xenobiotica. 18: 29-39. PMID: 3354230
  10. Reactivation of organophosphate-inhibited serum butyrylcholinesterase by novel substituted phenoxyalkyl pyridinium oximes and traditional oximes.  |  Nichols, RH. and Chambers, JE. 2021. Toxicology. 452: 152719. PMID: 33592259
  11. Confirmation of organothiophosphorus insecticide residues in fruit and vegetables by oxidative derivatization.  |  Singh, J. and Cochrane, WP. 1979. J Assoc Off Anal Chem. 62: 751-6. PMID: 500524
  12. Mechanism for OH-initiated atmospheric oxidation of the organophosphorus insecticide phorate  |  , et al. (2014). Structural Chemistry. volume 25,: pages 275–284.
  13. Hepatic and extrahepatic microsomal oxidation of phorate by the cytochrome P-450 and FAD-containing monooxygenase systems in the mouse  |  S Kinsler, PE Levi, E Hodgson - Pesticide Biochemistry and Physiology, 1988 - Elsevier. May 1988. Pesticide Biochemistry and Physiology. Volume 31, Issue 1,,: Pages 54-60.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Phorate Oxon, 10 mg

sc-478264
10 mg
$401.00