Molecular structure of PHOP, CAS Number: 288862-83-9
PHOP (CAS 288862-83-9)
Application:
PHOP is a potent FAAH inhibitor
CAS Number:
288862-83-9
Molecular Weight:
294.4
Molecular Formula:
C18H18N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
Phenyl hexanoyl oxazolopyridine (PHOP) is a potent FAAH inhibitor (Ki = 0.094 nM and 0.2 nM for the human and rat enzymes, respectively). Using a proteomics approach, PHOP was screened against the serine hydrolase family of enzymes, of which FAAH is a member. In this assay, PHOP exhibited IC50 values of 1.1 nM, 1.4 nM, and >100 μM for FAAH, triacylglycerol hydrolase (TGH), and an uncharacterized hydrolase (KIAA1363), respectively. Knowledge of the specificity of PHOP obtained from this experiment should allow for more accurate interpretation of results using this inhibitor in complex environments such as whole cells or animals.
PHOP (CAS 288862-83-9) References
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- Overview of the chemical families of fatty acid amide hydrolase and monoacylglycerol lipase inhibitors. | Vandevoorde, S. 2008. Curr Top Med Chem. 8: 247-67. PMID: 18289091
- High-performance liquid chromatographic assay with fluorescence detection for the evaluation of inhibitors against fatty acid amide hydrolase. | Forster, L., et al. 2009. Anal Bioanal Chem. 394: 1679-85. PMID: 19484225
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- Design, synthesis and evaluation of polar head group containing 2-keto-oxazole inhibitors of FAAH. | Rusch, M., et al. 2012. Bioorg Med Chem. 20: 1100-12. PMID: 22196515
- (4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL). | Holtfrerich, A., et al. 2013. Eur J Med Chem. 63: 64-75. PMID: 23455058
- 1-Heteroarylpropan-2-ones as inhibitors of fatty acid amide hydrolase: Studies on structure-activity relationships and metabolic stability. | Zahov, S., et al. 2017. Bioorg Med Chem. 25: 825-837. PMID: 27989417
- ω-Heteroarylalkylcarbamates as inhibitors of fatty acid amide hydrolase (FAAH)[J]. | Terwege T, Dahlhaus H, Hanekamp W. 2014. MedChemComm,. 5(7): 932-936.
Inhibitor of:
FAAH.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PHOP, 100 µg | sc-205433 | 100 µg | $56.00 | |||
PHOP, 500 µg | sc-205433A | 500 µg | $252.00 |