Phomopsin A (CAS 64925-80-0)
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Phomopsin A is a mycotoxin found in the fungus Phomopsis leptostromiformis and is the subject of research across several scientific disciplines. In the field of plant pathology, it is studied for its role in the development of lupinosis in livestock, a disease that can result from ingestion of lupins contaminated with the fungus. Research involving Phomopsin A also extends to the examination of the mechanisms of toxicity and the biosynthesis of mycotoxins in fungi. Mycologists and chemists are interested in understanding the genetic and enzymatic pathways that lead to its production. Furthermore, Phomopsin A serves as a reference compound in the development of analytical methods for the detection and quantification of mycotoxins in agricultural commodities. This compound′s interactions with cellular components are also studied to assess the risk it poses to ecosystems and to devise strategies for mycotoxin management.
Phomopsin A (CAS 64925-80-0) References
- Natural products which interact with tubulin in the vinca domain: maytansine, rhizoxin, phomopsin A, dolastatins 10 and 15 and halichondrin B. | Hamel, E. 1992. Pharmacol Ther. 55: 31-51. PMID: 1287674
- Interaction of phomopsin A with porcine brain tubulin. Inhibition of tubulin polymerization and binding at a rhizoxin binding site. | Li, Y., et al. 1992. Biochem Pharmacol. 43: 219-24. PMID: 1739410
- Effect of phomopsin A on the alkylation of tubulin. | Ludueña, RF., et al. 1990. Biochem Pharmacol. 39: 1603-8. PMID: 2337418
- Development and validation of an LC-MS/MS method for the detection of phomopsin A in lupin and lupin-containing retail food samples from the Netherlands. | de Nijs, M., et al. 2013. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 30: 1819-26. PMID: 23895245
- One-pot synthesis of vinca alkaloids-phomopsin hybrids. | Gherbovet, O., et al. 2014. J Med Chem. 57: 5470-6. PMID: 24871162
- Development of a SIDA-LC-MS/MS Method for the Determination of Phomopsin A in Legumes. | Schloß, S., et al. 2015. J Agric Food Chem. 63: 10543-9. PMID: 26567714
- The interaction of phomopsin A with bovine brain tubulin. | Ludueña, RF., et al. 1989. Arch Biochem Biophys. 272: 32-8. PMID: 2735765
- Instability and apparent lack of metabolism of phomopsin A during incubation with ovine rumen fluid. | Vogel, P. 1988. J Appl Toxicol. 8: 227-8. PMID: 3171082
- Impact of experimental thermal processing of artificially contaminated pea products on ochratoxin A and phomopsin A. | Kunz, BM., et al. 2021. Mycotoxin Res. 37: 63-78. PMID: 33068264
- Growth and toxin production of phomopsin A and ochratoxin A forming fungi under different storage conditions in a pea (Pisum sativum) model system. | Kunz, BM., et al. 2022. Mycotoxin Res. 38: 37-50. PMID: 34921667
- Interaction of phomopsin A and related compounds with purified sheep brain tubulin. | Lacey, E., et al. 1987. Biochem Pharmacol. 36: 2133-8. PMID: 3606630
- Phomopsin A production by Phomopsis leptostromiformis in liquid media. | Lanigan, GW., et al. 1979. Appl Environ Microbiol. 37: 289-92. PMID: 434808
- Interaction of phomopsin A with normal and subtilisin-treated bovine brain tubulin. | Chaudhuri, AR. and Ludueña, RF. 1997. J Protein Chem. 16: 99-105. PMID: 9112603
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Phomopsin A, 1 mg | sc-202282 | 1 mg | $490.00 | |||
Phomopsin A, 5 mg | sc-202282A | 5 mg | $1300.00 | |||
Phomopsin A, 10 mg | sc-202282B | 10 mg | $2200.00 |