Phomopsin A CAS: 64925-80-0
MF: C36H45ClN6O12
MW: 789.2
A potent microtubule inhibitor.

Phomopsin A (CAS 64925-80-0)

Phomopsin A | CAS 64925-80-0 is rated 5.0 out of 5 by 1.
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Synonym: (E)-2-[[(E)-2-[[(2S)-1-[(2S,3S,6S,9S,10R)-14-chloro-10-ethyl-2,13-dihydroxy-10-methyl-3-(methylamino)-4,7-dioxo-6-prop-1-en-2-yl-11-oxa-5,8-diazabicyclo[10.3.1]hexadeca-1(16),12,14-triene-9-carbonyl]-2,5-dihydropyrrole-2-carbonyl]amino]-3-methylpent-2-enoyl]amino]but-2-enedioic acid
Application: A potent microtubule inhibitor
CAS Number: 64925-80-0
Purity: >98%
Molecular Weight: 789.2
Molecular Formula: C36H45ClN6O12
* Refer to Certificate of Analysis for lot specific data (including water content).
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Phomopsin A, a peptide mycotoxin originally derived from Phomopsis leptostromiformis, has been shown to be a potent microtubule inhibitor. Mechanistic studies suggest that the inhibition of polymerization of tubulin takes place via suppression of [3H]vinblastine binding to tubulin and enhancement of Colchicine (sc-203005) to tubulin. More specific studies report that Phompsin A exerts its action on tubulin through interaction near the vinblastine binding site.


References

1. Lacey, E., et al. 1987. Biochem. Pharmacol. 36: 2133-2138. PMID: 3606630
2. Ludueña, R.F., et al. 1990. Biochem. Pharmacol. 39: 1603-1608. PMID: 2337418
3. Chaudhuri, A.R., et al. 1997. J. Protein Chem. 16: 99-105. PMID: 9112603

Physical State :
Solid
Derived From :
Phomposis leptostromiformis
Solubility :
Soluble in ethanol, methanol, DMF or DMSO. Slightly soluble in water.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
SY2593000
PubChem CID :
6438581
SMILES :
CCC(=C(C(=O)NC(=CC(=O)O)C(=O)O)NC(=O)C1C=CCN1C(=O)C2C(OC3=C(C(=CC(=C3)C(C(C(=O)NC(C(=O)N2)C(=C)C)NC)O)Cl)O)(C)CC)C

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Certificate of Analysis

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Phomopsin A  Product Citations

See how others have used Phomopsin A. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26567714  Schloß, S. et al. 2015. J. Agric. Food Chem. 63: 10543-9.

Citations 1 to 1 of 1 total

How is Phomopsin A used?

Asked by: SCM4
This Chemical, Phomopsin A, was used in the 1997 publication “Interaction of phomopsin A with normal and subtilisin-treated bovine brain tubulin.” (PMID: 9112603) by Chaudhuri et. al. Phomopsin A is shown to “inhibit the decay process of alpha(s) beta(s) tubulin”.
Answered by: Chemical Support 1
Date published: 2017-03-24

The phomopsin A standard was dissolved in methanol and analyzed by LC-MS. As a result, there are two peaks of the same mass value. Is there an isomer in the Phomopsin A standard?

Asked by: Mins
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Rated 5 out of 5 by from Phomopsin A was reported as a metabolite Phomopsin A was reported as a metabolite mainly produced by the fungus Diaporthe toxica, in many articles. -SCBT Publication Review
Date published: 2015-04-22
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