PHM27 Antibody (020-03): sc-57400

PHM27 Antibody (020-03) is a mouse monoclonal IgG2a antibody that detects PHM27 protein of human origin by enzyme-linked immunosorbent assay (ELISA). Anti-PHM27 antibody (020-03) is available as the non-conjugated format, providing researchers with a reliable tool for studying this important peptide. The peptide histidine methionine 27 (PHM27) is a biologically significant peptide that contains an N-terminal histidine and a C-terminal methionine amide, and plays a crucial role in regulating insulin secretion. PHM27 is closely related to vasoactive intestinal peptide (VIP), as both are encoded by adjacent exons and work synergistically to enhance glucose-induced insulin secretion from pancreatic beta cells through an autocrine mechanism. This interaction maintains glucose homeostasis, and dysregulation of PHM27 or VIP can contribute to metabolic disorders such as diabetes. PHM27 has been shown to inhibit calcitonin binding to receptors, indicating a potential role in modulating calcium homeostasis and bone metabolism. PHM27′s influence on insulin secretion and interactions with other peptides makes this protein a valuable target for therapeutic strategies aimed at improving insulin sensitivity and secretion in clinical diabetes.

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PHM27 Antibody (020-03) References:

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