Philanthotoxin 433 tris(trifluoroacetate) salt (CAS 276684-27-6)
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Philanthotoxin 433 tris(trifluoroacetate) salt, often abbreviated as PhTX-433, is a polyamine-containing toxin found in the venom of the wasp Philanthus triangulum. It is known for its specific action on ion channels, particularly its inhibition of NMDA (N-methyl-D-aspartate) receptors, which are for synaptic transmission and plasticity in the central nervous system. This toxin operates by binding to the open channel form of NMDA receptors, thereby obstructing the flow of ions such as calcium, sodium, and potassium across the cell membrane. This blockade can modulate the receptor′s function, makingPhilanthotoxin 433 tris(trifluoroacetate) salt useful in neurophysiological research for understanding synaptic processes, the mechanisms underlying excitatory neurotransmission, and the pathophysiology of diseases characterized by NMDA receptor dysfunction. Its utility in research extends to the exploration of the structural and functional dynamics of ion channels, contributing to the broader field of neuropharmacology and the development of strategies for targeting these channels in various neurological conditions.
Philanthotoxin 433 tris(trifluoroacetate) salt (CAS 276684-27-6) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Philanthotoxin 433 tris(trifluoroacetate) salt, 1 mg | sc-255421 | 1 mg | $612.00 |