Molecular structure of Phenylhexyl isothiocyanate, CAS Number: 133920-06-6
Phenylhexyl isothiocyanate (CAS 133920-06-6)
Alternate Names:
6-Phenylhexyl isothiocyanate; PHITC
Application:
Phenylhexyl isothiocyanate is used to study tumorigenesis in mice and rats
CAS Number:
133920-06-6
Purity:
>98%
Molecular Weight:
219.35
Molecular Formula:
C13H17NS
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Phenylhexyl isothiocyanate is a chemopreventive agent in mouse lung, however, it has been found to enhance colon and esophageal tumorigenesis in rats.
Phenylhexyl isothiocyanate (CAS 133920-06-6) References
- Phenylhexyl isothiocyanate inhibits histone deacetylases and remodels chromatins to induce growth arrest in human leukemia cells. | Ma, X., et al. 2006. Int J Oncol. 28: 1287-93. PMID: 16596246
- Epigenetic mechanism of growth inhibition induced by phenylhexyl isothiocyanate in prostate cancer cells. | Beklemisheva, AA., et al. 2006. Anticancer Res. 26: 1225-30. PMID: 16619528
- The phenylhexyl isothiocyanate induces apoptosis and inhibits leukemia cell growth in vivo. | Lu, L., et al. 2006. Oncol Rep. 16: 1363-7. PMID: 17089062
- Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways. | Lu, Q., et al. 2008. J Hematol Oncol. 1: 6. PMID: 18577263
- [Phenylhexyl isothiocyanate induces gene p15 demethylation by down-regulating DNA methyltransferases in Molt-4 cells]. | Jiang, SH., et al. 2009. Yao Xue Xue Bao. 44: 350-4. PMID: 19545050
- Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. | Morse, MA., et al. 1991. Cancer Res. 51: 1846-50. PMID: 2004368
- Synergistic effects of phenylhexyl isothiocyanate and LY294002 on the PI3K/Akt signaling pathway in HL-60 cells. | Yang, H., et al. 2017. Oncol Lett. 14: 3043-3050. PMID: 28927052
- Phenylhexyl isothiocyanate suppresses cell proliferation and promotes apoptosis via repairing mutant P53 in human myeloid leukemia M2 cells. | Zou, Y., et al. 2019. Oncol Lett. 18: 3358-3366. PMID: 31452815
- Enhancement of esophageal carcinogenesis in male F344 rats by dietary phenylhexyl isothiocyanate. | Stoner, GD., et al. 1995. Carcinogenesis. 16: 2473-6. PMID: 7586154
- Enhancement of experimental colon carcinogenesis by dietary 6-phenylhexyl isothiocyanate. | Rao, CV., et al. 1995. Cancer Res. 55: 4311-8. PMID: 7671241
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Phenylhexyl isothiocyanate, 100 mg | sc-204844 | 100 mg | $160.00 | |||
Phenylhexyl isothiocyanate, 250 mg | sc-204844A | 250 mg | $315.00 |