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Phenylhexyl isothiocyanate is a chemopreventive agent in mouse lung, however, it has been found to enhance colon and esophageal tumorigenesis in rats.
1. Morse, M A., et al., 1991. Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice. Cancer research. 51(7): 1846-50. PMID: 2004368
2. Stoner, G D., et al., 1995. Enhancement of esophageal carcinogenesis in male F344 rats by dietary phenylhexyl isothiocyanate. Carcinogenesis. 16(10): 2473-6. PMID: 7586154
3. Rao, C V., et al., 1995. Enhancement of experimental colon carcinogenesis by dietary 6-phenylhexyl isothiocyanate. Cancer research. 55(19): 4311-8. PMID: 7671241
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