Date published: 2025-9-25

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Phenylboronic acid (CAS 98-80-6)

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Alternate Names:
Benzeneboronic acid
Application:
Phenylboronic acid is used in organic synthesis cross coupling reactions
CAS Number:
98-80-6
Purity:
≥97%
Molecular Weight:
121.93
Molecular Formula:
C6H7BO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Phenylboronic acid is a boronic acid containing a phenyl substituent and two hydroxyl groups attached to boron. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis including numerous cross coupling reactions. Phenylboronic acid is often used as a reagent in the C-C bond forming processes, and Heck-type cross coupling of phenylboronic acid to alkenes and alkynes. Phenylboronic acid can be used as a protecting group for diols and diamines, and in regioselectively halodeboronated using aqueous bromine, chlorine, or iodine.


Phenylboronic acid (CAS 98-80-6) References

  1. Recent progress in electrochemical biosensors based on phenylboronic acid and derivatives.  |  Anzai, JI. 2016. Mater Sci Eng C Mater Biol Appl. 67: 737-746. PMID: 27287174
  2. Recent Advances in Phenylboronic Acid-Based Gels with Potential for Self-Regulated Drug Delivery.  |  Wang, C., et al. 2019. Molecules. 24: PMID: 30893913
  3. Advances in phenylboronic acid-based closed-loop smart drug delivery system for diabetic therapy.  |  Huang, Q., et al. 2019. J Control Release. 305: 50-64. PMID: 31112719
  4. Lactoferrin/phenylboronic acid-functionalized hyaluronic acid nanogels loading doxorubicin hydrochloride for targeting glioma.  |  Zhang, M., et al. 2021. Carbohydr Polym. 253: 117194. PMID: 33278970
  5. Phenylboronic acid-conjugated chitosan nanoparticles for high loading and efficient delivery of curcumin.  |  Wang, J., et al. 2021. Carbohydr Polym. 256: 117497. PMID: 33483024
  6. Bioresponsive Functional Phenylboronic Acid-Based Delivery System as an Emerging Platform for Diabetic Therapy.  |  Ma, Q., et al. 2021. Int J Nanomedicine. 16: 297-314. PMID: 33488074
  7. Injectable DMEM-induced phenylboronic acid-modified hyaluronic acid self-crosslinking hydrogel for potential applications in tissue repair.  |  Gao, H., et al. 2021. Carbohydr Polym. 258: 117663. PMID: 33593547
  8. Stimuli-Responsive Multifunctional Phenylboronic Acid Polymers Via Multicomponent Reactions: From Synthesis to Application.  |  Zeng, Y., et al. 2021. Macromol Rapid Commun. 42: e2100022. PMID: 33713503
  9. Phenylboronic acid-functionalized silver nanoparticles for highly efficient and selective bacterial killing.  |  Wang, H., et al. 2022. J Mater Chem B. 10: 2844-2852. PMID: 35293932
  10. Phenylboronic acid as a novel agent for controlling plant pathogenic bacteria.  |  Martinko, K., et al. 2022. Pest Manag Sci. 78: 2417-2422. PMID: 35301783
  11. Phenylboronic acid-modified polymaleic anhydride-F127 micelles for pH-activated targeting delivery of doxorubicin.  |  Feng, R., et al. 2022. Colloids Surf B Biointerfaces. 216: 112559. PMID: 35576880
  12. Phenylboronic acid modified hydrogel materials and their potential for use in contact lens based drug delivery.  |  Liu, L., et al. 2022. J Biomater Sci Polym Ed. 33: 1924-1938. PMID: 35695022
  13. Rheological analysis of a novel phenylboronic acid-closomer gel.  |  Akinjole, O., et al. 2022. Int J Pharm. 626: 122070. PMID: 36041591
  14. Phenylboronic Acid-Functionalized Polyplexes Tailored to Oral CRISPR Delivery.  |  Yoshinaga, N., et al. 2023. Nano Lett. 23: 757-764. PMID: 36648291

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Phenylboronic acid, 10 g

sc-255419
10 g
$53.00

Phenylboronic acid, 50 g

sc-255419A
50 g
$138.00

Phenylboronic acid, 500 g

sc-255419B
500 g
$300.00

Phenylboronic acid, 2.5 kg

sc-255419C
2.5 kg
$675.00