Phenylarsine oxide: sc-3521. Western blot analysis of Cofilin 1 phosphorylation in K-562 (A), lambda phosphatase (sc-200312) treated K-562 (B), Phenylarsine oxide treated K-562 (C) and Phenylarsine oxide and lambda phosphatase treated K-562 (D). Antibody tested: p-Cofilin 1 (H-2): sc-271923. Note inhibition of lambda phosphatase by Phenylarsine oxide in lane D.
Phenylarsine oxide (CAS 637-03-6)
See product citations (4)
Alternate Names:
PAO; Arzene; Oxophenylarsine
Application:
Phenylarsine oxide is a membrane-permeable PTPase inhibitor
CAS Number:
637-03-6
Molecular Weight:
168.02
Molecular Formula:
C6H5AsO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Phenylarsine Oxide is a membrane-permeable protein-tyrosine phosphatase (PTPase) inhibitor with no effect on tyrosine kinase. It inhibits the internalization of cell surface receptors. Phenylarsine Oxide is very useful in the study of tyrosine phosphorylation events and the mechanisms that inhibit or block tyrosine phosphorylation. One report applied Phenylarsine Oxide and TNF to human myeloid cells (ML-1a) to study TNF-dependent NFkappaB activation. Phenylarsine Oxide has been reported to stimulate 2-deoxyglucose transport in insulin-resistant human skeletal muscle and activates Lck (lymphocyte-specific protein tyrosine kinase). Since Phenylarsine Oxide is also an inhibitor of caspases and nuclear apoptotic events, it is useful for the study of apoptosis.
Phenylarsine oxide (CAS 637-03-6) References
- Phenylarsine oxide (PAO) more intensely induces apoptosis in acute promyelocytic leukemia and As2O3-resistant APL cell lines than As2O3 by activating the mitochondrial pathway. | Sahara, N., et al. 2004. Leuk Lymphoma. 45: 987-95. PMID: 15291359
- Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide. | Lillig, CH., et al. 2004. Proc Natl Acad Sci U S A. 101: 13227-32. PMID: 15328416
- Phenylarsine oxide is able to dissipate synaptic vesicle acidic pool. | Tarasenko, AS., et al. 2005. Neurochem Int. 46: 541-50. PMID: 15843048
- Phenylarsine oxide and the mechanism of insulin-stimulated sugar transport. | Douen, AG. and Jones, MN. 1990. Biofactors. 2: 153-61. PMID: 2165780
- Phenylarsine oxide as a redox modulator of transient receptor potential vanilloid type 1 channel function. | Carlin, KP., et al. 2015. J Neurosci Res. 93: 309-20. PMID: 25250537
- Phenylarsine Oxide Can Induce the Arsenite-Resistance Mutant PML Protein Solubility Changes. | Jiang, YH., et al. 2017. Int J Mol Sci. 18: PMID: 28125064
- Phenylarsine oxide (PAO) induces apoptosis in HepG2 cells via ROS-mediated mitochondria and ER-stress dependent signaling pathways. | Huang, P., et al. 2017. Metallomics. 9: 1756-1764. PMID: 28831476
- Phenylarsine Oxide Can Induce Degradation of PLZF-RARα Variant Fusion Protein of Acute Promyelocytic Leukemia. | Hussain, L., et al. 2019. Chem Res Toxicol. 32: 548-550. PMID: 30869512
- Complete and reversible inhibition of NADPH oxidase in human neutrophils by phenylarsine oxide at a step distal to membrane translocation of the enzyme subunits. | Le Cabec, V. and Maridonneau-Parini, I. 1995. J Biol Chem. 270: 2067-73. PMID: 7530716
- Protein-tyrosine phosphatase inhibitors block tumor necrosis factor-dependent activation of the nuclear transcription factor NF-kappa B. | Singh, S. and Aggarwal, BB. 1995. J Biol Chem. 270: 10631-9. PMID: 7738000
- Okadaic acid, vanadate, and phenylarsine oxide stimulate 2-deoxyglucose transport in insulin-resistant human skeletal muscle. | Carey, JO., et al. 1995. Diabetes. 44: 682-8. PMID: 7789633
- Induction of hyperphosphorylation and activation of the p56lck protein tyrosine kinase by phenylarsine oxide, a phosphotyrosine phosphatase inhibitor. | Oetken, C., et al. 1994. Mol Immunol. 31: 1295-302. PMID: 7997241
- Phenylarsine oxide (PAO) blocks antigen receptor-induced calcium response and tyrosine phosphorylation of a distinct group of proteins. | Rozsnyay, Z., et al. 1993. Immunol Lett. 37: 197-205. PMID: 8258460
- Phenylarsine oxide (PAO)-mediated activation of phospholipase D in rat basophilic leukemia (RBL-2H3) cells: possible involvement of calcium and protein kinase C. | Kumada, T., et al. 1996. Immunobiology. 195: 347-59. PMID: 8877408
- Inhibition of ICE-related proteases (caspases) and nuclear apoptosis by phenylarsine oxide. | Takahashi, A., et al. 1997. Exp Cell Res. 231: 123-31. PMID: 9056419
Inhibitor of:
α-defensin 6, 3-Hydroxybutyrate Dehydrogenase, 4921523A10Rik, 4930432O21Rik, 5730403M16Rik, 9130014G24Rik, 9230107M04Rik, AGAP1, AGXT2, AKR1CL2, Anamorsin, apoL7c, apoL7e, Arylsulfatase D, Arylsulfatase E, Arylsulfatase F, Arylsulfatase K, AU017455, AY026312, BLVRA, CaBP8, Calumenin, Caspase, CBR4, Cdc25A, Cdc50B, Chemical and Peptide Caspase, CYB5D1, dsg1β, DUSP20, ECHDC1, EG665927, epsin, Ero1-Lα, Exocyst complex component (EXOC), FAM173A, Fap-1, FucU, GOLPH4, Gtlf3a, GUF1, HscB, Kell, Keratin 71, KRTAP12-2, KRTAP2-2, KRTAP4-8, Lipocalin-10, LPPR3, LRRC14B, LRRC68, LYPLA1, Mcsp, MIPP, Morc2b, MORN2, MYPT1, NAALADL1, NAG-2, NECAP 2, Nkx-6, OCRL, OCRL1, OR52E5, OST-PTP, OXNAD1, PADI3, PAP-2c, PDI1 ER and Nuclear Envelope Marker, PDIR, PHI-1, PHLPPL, phosphatasefamily surface anchored protein, Phosphogluco-mutase, PI 4-kinase II β, PIPK I α, PITP, PP2A-β, PP2A-δ, PP2B-Aβ, PPIAL4C, PPIAL4G, Protein tyrosine phosphatase receptor (PTPR), PTP-H1, PTP-MEG2, PTPδ, PTPλ, PTPψ, PTPρ, PTPDC1, PTPN20, PTPN20A, PTPN20B, PTPy, PYROXD1, Rab 3 GAP p150, Rab 40AL, Rab 41, Rabenosyn-5, RP23-110D11.1, SDHAF1, SDHAF2, SDHC, Sec23IP, Sec24, Sec4, Selenoprotein M, SH-PTP1, SPACA5, TBG, TMPPE, Transaldolase, TXNDC1, Type I 4-phoshatase α, Type I 4-phoshatase β, Type II 4-phoshatase, Type II 4-phoshatase β, TYW3, V1RI9, VHX, Vmn2r50, VWCE, XylT-I, ZDHHC9, ZFP1, ZFP773, ZIP3, ZNF202, ZNF256, ZNF589, and ZNF598.Activator of:
2010005H15Rik, ALG6, ARL15, B430203M17Rik, Bestatin, cathepsin 3, CD45RC, Cdc14b Phosphatase, Centaurin β5, Clathrin LCB, CYP, DEP-1, DEPDC6, DUSP22, DUSP24, DUSP26, DUSP28, Dynamin II, FKBP52, GLTPD2, Maspardin, MBLAC2, NXF3, ORP-11, OS4, PIG-C, Pin1l, PP2A-Bα, PTEN, PTP 1β, Pyhin1, Rab 30, RPTPα, S2P, Selenoprotein O, SerpinA1b, Ski2, SUMF2, VHR, WDR78, ZC3H7A, and ZFP772.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Phenylarsine oxide, 250 mg | sc-3521 | 250 mg | $41.00 |