Date published: 2026-5-21

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Phenyl thiocyanate (CAS 5285-87-0)

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CAS Number:
5285-87-0
Molecular Weight:
135.19
Molecular Formula:
C7H5NS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Phenyl thiocyanate (PTC) has a wide range of applications in organic synthesis, analytical chemistry, and biochemistry. In organic synthesis, Phenyl thiocyanate serves as a reactant for the production of various organic compounds, while also functioning as a catalyst in diverse reactions. Moreover, it finds use as a reagent in the detection of specific compounds and as a probe for studying enzyme-catalyzed reactions. Within the realm of scientific research, Phenyl thiocyanate holds significant value. It is employed as a reactant in organic synthesis, a catalyst in diverse reactions, and a reagent for the detection of specific compounds. Furthermore, it contributes to the study of enzyme-catalyzed reactions, facilitating investigations into enzyme kinetics and inhibition. Operating as an electrophilic reagent, Phenyl thiocyanate engages with nucleophiles such as amines, alcohols, and thiols. The reaction is hypothesized to follow a nucleophilic addition-elimination mechanism, involving the initial addition of the nucleophile to the electrophilic carbon of the thiocyanate, followed by the elimination of the thiocyanate anion. Beyond its applications in chemical processes, Phenyl thiocyanate has exhibited noteworthy effects in other domains. Studies have demonstrated its antiproliferative properties against specific cancer cell types, including breast and prostate cancer cells. Additionally, it has been identified as possessing anti-inflammatory and antioxidant attributes, further broadening its potential applications.


Phenyl thiocyanate (CAS 5285-87-0) References

  1. Activation of aryl thiocyanates followed by aryne insertion: access to 1,2-thiobenzonitriles.  |  Pawliczek, M., et al. 2015. Org Lett. 17: 1716-9. PMID: 25775431
  2. Gas chromatography-mass spectrometric identification of cyanide using a nucleophilic substitution based derivatization with S-phenyl benzenethiosulfonate.  |  Goud, DR., et al. 2020. Anal Methods. 12: 5839-5845. PMID: 33227115
  3. The effects of solvents on the stretching vibrations of the thiocyanate and isothiocyanate groups  |  RA Cummins. 1964. Australian Journal of Chemistry. 17(8): 838 - 850.
  4. The Reaction of Arylthallium(III) Compounds with Copper(II) and (I) Thiocyanates  |  Uemura Sakae 1, Uchida Satoru 1, Okano Masaya 1, Ichikawa Katsuhiko 2. 1973,. Bulletin of the Chemical Society of Japan. Vol.46, No.10: 3254-3257.
  5. Reactivity of nucleophiles toward and the site of nucleophilic attack on phenyl benzenethiolsulfinate  |  John L. Kice and Chao-Chuin A. Liu. 1979. J. Org. Chem. 44, 12: 1918–1923.
  6. Plasma polymerization of phenyl isothiocyanate  |   and G. Czeremuszkin, A. M. Wróbel, M. Kryszewski. April 1986. Journal of Polymer Science Part A: Polymer Chemistry. Volume24, Issue4: Pages 715-726.
  7. Photochemical reactions of polystyrenes ring-substituted with thiocyanato groups  |   and Wolfgang Kern, Josefine Hobisch, Klaus Hummel. December 1997. Macromolecular Chemistry and Physics. Volume198, Issue12: Pages 3987-3999.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Phenyl thiocyanate, 1 g

sc-358507
1 g
$437.00

Phenyl thiocyanate, 5 g

sc-358507A
5 g
$1265.00