Phenethyl isothiocyanate (CAS 2257-09-2)

Phenethyl isothiocyanate (PEITC) is a naturally occurring compound found in cruciferous vegetables, such as broccoli, brussels sprouts, and watercress. As a member of the isothiocyanate group of chemicals, Phenethyl isothiocyanate has been extensively studied for its unique mechanism of action, primarily focusing on its ability to modulate cellular pathways related to detoxification and the regulation of reactive oxygen species. Its role in research is highlighted by its effectiveness in inducing phase II detoxification enzymes, which are for the metabolism and elimination of carcinogens from the body. Furthermore, Phenethyl isothiocyanate may act to inhibit the activation of NF-κB, a protein complex that plays a key role in regulating the immune response to infection. This compound also exhibits an ability to induce apoptosis in certain types of cancer cells by disrupting mitochondrial functions and promoting the release of cytochrome c, leading to the activation of caspases involved in the apoptotic pathway. The research interest in Phenethyl isothiocyanate continues to grow due to its potential impact on understanding the molecular mechanisms underlying the chemopreventive effects of certain diets and its role in the modulation of key cellular processes.