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Phenazopyridine hydrochloride (CAS 136-40-3)

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Alternate Names:
2,6-Diamino-3-(phenylazo)pyridine hydrochloride; Urodine; Pyripyridium
Application:
Phenazopyridine hydrochloride is a compound which can be used as an analgesic for the urinary tract
CAS Number:
136-40-3
Molecular Weight:
249.70
Molecular Formula:
C11H11N5•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Phenazopyridine, Hydrochloride is a chemical that functions as a urinary tract analgesic. Its mechanism of action involves exerting a local analgesic effect on the urinary tract mucosa. Phenazopyridine hydrochloride is able to provide relief from pain, burning, and discomfort caused by irritation of the lower urinary tract. It achieves this by exerting a topical analgesic effect on the mucosa of the urinary tract, the bladder and urethra. Phenazopyridine, Hydrochloride acts by directly targeting and inhibiting the irritation and pain receptors in the urinary tract, thereby reducing the sensation of discomfort and pain. Phenazopyridine hydrochloride ′s mode of action involves blocking the transmission of pain signals from the urinary tract to the brain, resulting in a reduction in the perception of pain and discomfort.


Phenazopyridine hydrochloride (CAS 136-40-3) References

  1. Bioassay of phenazopyridine hydrochloride for possible carcinogenicity.  |  ,. 1978. Natl Cancer Inst Carcinog Tech Rep Ser. 99: 1-115. PMID: 12806392
  2. 1H, 13C and 15N NMR assignments of phenazopyridine derivatives.  |  Burgueño-Tapia, E., et al. 2005. Magn Reson Chem. 43: 256-60. PMID: 15625718
  3. Determination of phenazopyridine in human plasma via LC-MS and subsequent development of a pharmacokinetic model.  |  Shang, E., et al. 2005. Anal Bioanal Chem. 382: 216-22. PMID: 15900475
  4. Evaluation of phenazopyridine hydrochloride as a tool in the diagnosis of premature rupture of the membranes.  |  Meyer, BA., et al. 1991. Am J Perinatol. 8: 297-9. PMID: 1760061
  5. Development and validation of a gas chromatography-mass spectrometry method for the determination of phenazopyridine in rat plasma: application to the pharmacokinetic study.  |  Chen, Q., et al. 2007. Biopharm Drug Dispos. 28: 439-44. PMID: 17847064
  6. Adsorptive stripping voltammetric assay of phenazopyridine hydrochloride in biological fluids and pharmaceutical preparations.  |  Sabry, SM. 1999. Talanta. 50: 133-40. PMID: 18967703
  7. Experimental design of membrane sensor for selective determination of phenazopyridine hydrochloride based on computational calculations.  |  Attia, KA., et al. 2016. Mater Sci Eng C Mater Biol Appl. 61: 773-81. PMID: 26838908
  8. Application of an HPLC Method for Selective Determination of Phenazopyridine Hydrochloride: Theoretical and Practical Investigations.  |  Attia, KAM., et al. 2017. J AOAC Int. 100: 1400-1406. PMID: 28421989
  9. Simultaneous determination of phenazopyridine HCl and trimethoprim in presence of phenazopyridine HCl impurity by univariate and multivariate spectrophotometric methods - Quantification of phenazopyridine HCl impurity by univariate methods.  |  Soudi, AT., et al. 2020. Spectrochim Acta A Mol Biomol Spectrosc. 239: 118516. PMID: 32492634
  10. High-performance liquid chromatographic determination of phenazopyridine hydrochloride, tetracycline hydrochloride and sulphamethizole in combination.  |  Du Preez, JL., et al. 1985. J Chromatogr. 333: 249-52. PMID: 4066840
  11. Amperometric determination of phenazopyridine hydrochloride in a flowing stream at the glassy carbon electrode.  |  Belal, F. 1985. J Assoc Off Anal Chem. 68: 1207-9. PMID: 4086443
  12. Rapid increase in calculous size: a possible hazard of phenazopyridine hydrochloride therapy in the presence of already formed stones.  |  Crawford, ED. and Mulvaney, WP. 1978. J Urol. 119: 280-1. PMID: 633496
  13. Comparison of structure of nano zinc metal–organic frameworks upon uptake and release of phenazopyridine hydrochloride  |  Abbasi, A. R., & Hatami, S. 2017. Journal of Inorganic and Organometallic Polymers and Materials. 27: 1941-1949.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Phenazopyridine hydrochloride, 100 mg

sc-212544
100 mg
$114.00