Molecular structure of Phallacidin, CAS Number: 26645-35-2
Phallacidin (CAS 26645-35-2)
See product citations (4)
Application:
Phallacidin is an F-actin stabilizing toxin useful for conjugation to fluorescent molecules to actin filaments
CAS Number:
26645-35-2
Purity:
≥90%
Molecular Weight:
846.9
Molecular Formula:
C37H50N8O13S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Phallacidin is a member of the phallotoxin family of mushroom toxins isolated from Amanita phalloides with biological activity similar to Phalloidin (sc-202763), which binds and stabilizes filamentous F-actin, preventing the dissociation of paired filaments and disturbing the natural equilibrium between filamentous (polymeric) and globular (monomeric) actin in the cell. Actin is used by the cell for mechanical processes such as growth, scaffolding of the cytoskeleton, and locomotion, and disruption of this actin equilibrium destroys cellular functioning. This product has a carboxy group that Phalloidin does not, making it useful for coupling reactions to fluorescent molecules.
Phallacidin (CAS 26645-35-2) References
- Phallacidin stains the mitotic spindle of the diatom Pinnularia spp. | Sampson, K. 2004. Cell Biol Int. 28: 565-9. PMID: 15350590
- Ribosomal biosynthesis of the cyclic peptide toxins of Amanita mushrooms. | Walton, JD., et al. 2010. Biopolymers. 94: 659-64. PMID: 20564017
- Amatoxin and phallotoxin concentration in amanita bisporigera spores. | Mcknight, TA., et al. 2010. Mycologia. 102: 763-5. PMID: 20648744
- Cytotoxicity on L1210 leukemic cells of beta-amanitin-concanavalin A and phallacidin-concanavalin A conjugates. | Zhelev, Z., et al. 1990. Toxicon. 28: 1360-3. PMID: 2087697
- Peptide toxin components of Amanita exitialis basidiocarps. | Deng, WQ., et al. 2011. Mycologia. 103: 946-9. PMID: 21471295
- Phallacidin prevents thrombin-induced increases in endothelial permeability to albumin. | Phillips, PG., et al. 1989. Am J Physiol. 257: C562-7. PMID: 2782396
- Toxin components and toxicological importance of Galerina marginata from Turkey. | Akata, I., et al. 2020. Toxicon. 187: 29-34. PMID: 32866473
- Analysis of Five Mushroom Toxins in Blood by UPLC-HRMS. | Liu, WQ., et al. 2021. Fa Yi Xue Za Zhi. 37: 646-652. PMID: 35187916
- In vivo staining of cytoskeletal actin by autointernalization of nontoxic concentrations of nitrobenzoxadiazole-phallacidin. | Barak, LS., et al. 1981. J Cell Biol. 89: 368-72. PMID: 6166616
- Fluorescence staining of the actin cytoskeleton in living cells with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin. | Barak, LS., et al. 1980. Proc Natl Acad Sci U S A. 77: 980-4. PMID: 6928695
Activator of:
Vac17p.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Phallacidin, 1 mg | sc-204840 | 1 mg | $209.00 |