PHACS Antibody (MA-02): sc-130477
- PHACS Antibody (MA-02) is a mouse monoclonal IgG3 κ PHACS antibody provided at 100 µg/ml
- raised against recombinant PHACS of human origin
- recommended for detection of PHACS of human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PHACS Antibody (MA-02). This work is in progress.
QUICK LINKS
SEE ALSO...
PHACS Antibody (MA-02) is a mouse monoclonal IgG3 kappa light chain antibody that detects PHACS protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-PHACS antibody (MA-02) is available as non-conjugated format. PHACS protein, also known as putative human ACS or ACC (1-aminocyclopropane-1-carboxylate synthase homolog), is a 501 amino acid enzyme that plays a crucial role in various metabolic processes. PHACS belongs to the alpha family of pyridoxal-5-prime-phosphate enzymes and is expressed in a wide range of human tissues, indicating importance in physiological functions. Notably, PHACS shares structural similarities with aspartate aminotransferase and tyrosine aminotransferase, which are involved in amino acid metabolism. PHACS features overlapping aminotransferase I and beta-eliminating lyase domains, which are essential for enzymatic activity. While plant homolog, ACS, is a key player in biosynthesis of phytohormone ethylene—vital for plant growth and development—PHACS does not catalyze synthesis of 1-aminocyclopropane-1-carboxylate, highlighting distinct functional role in human biology. Understanding PHACS function is important as this research may provide insights into metabolic pathways and potential therapeutic targets for various diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PHACS Antibody (MA-02) References:
- Structure of 1-aminocyclopropane-1-carboxylate synthase, a key enzyme in the biosynthesis of the plant hormone ethylene. | Capitani, G., et al. 1999. J Mol Biol. 294: 745-56. PMID: 10610793
- L-Vinylglycine is an alternative substrate as well as a mechanism-based inhibitor of 1-aminocyclopropane-1-carboxylate synthase. | Feng, L. and Kirsch, JF. 2000. Biochemistry. 39: 2436-44. PMID: 10704193
- Characterization of the recombinase activating gene-1 and 2 locus in the Japanese pufferfish, Fugu rubripes. | Peixoto, BR., et al. 2000. Gene. 246: 275-83. PMID: 10767549
- Aminotransferase activity and bioinformatic analysis of 1-aminocyclopropane-1-carboxylate synthase. | Feng, L., et al. 2000. Biochemistry. 39: 15242-9. PMID: 11106504
- The human cDNA for a homologue of the plant enzyme 1-aminocyclopropane-1-carboxylate synthase encodes a protein lacking that activity. | Koch, KA., et al. 2001. Gene. 272: 75-84. PMID: 11470512
- Structure of ACC synthase inactivated by the mechanism-based inhibitor L-vinylglycine. | Capitani, G., et al. 2005. FEBS Lett. 579: 2458-62. PMID: 15848188
- Characterization of a 1-aminocyclopropane-1-carboxylate synthase gene from loblolly pine (Pinus taeda L.). | Barnes, JR., et al. 2008. Gene. 413: 18-31. PMID: 18328643
- Enzymes that regulate ethylene levels--1-aminocyclopropane-1-carboxylic acid (ACC) deaminase, ACC synthase and ACC oxidase. | Penrose, DM. and Glick, BR. 1997. Indian J Exp Biol. 35: 1-17. PMID: 9279127
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PHACS Antibody (MA-02) | sc-130477 | 100 µg/ml | $333.00 |