Molecular structure of Phaclofen, CAS Number: 114012-12-3
Phaclofen (CAS 114012-12-3)
Alternate Names:
(±)-3-Amino-2-(4-chlorophenyl)-propylphosphomic acid
Application:
Phaclofen is a selective GABAB receptor antagonist
CAS Number:
114012-12-3
Purity:
98%
Molecular Weight:
249.6
Molecular Formula:
C9H13ClNO3P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Phaclofen is primarily used in neuroscience research to study the function and role of GABA B receptors. Researchers utilize Phaclofen to investigate how these receptors influence neurological processes such as neurotransmission and neuromodulation. This chemical acts as a selective GABA B receptor antagonist, which means it blocks the action of the neurotransmitter GABA at these receptor sites, thereby aiding in the exploration of GABAergic signaling pathways. This mechanism makes Phaclofen a useful tool in experiments designed to understand conditions related to neurotransmitter imbalances. Additionally, Phaclofen is employed in studies examining the plasticity of synaptic connections, which has implications for understanding learning and memory.
Phaclofen (CAS 114012-12-3) References
- Bicuculline- and Phaclofen-Resistant Hyperpolarizations Evoked by Glutamate Applications to Stratum Lacunosum-Moleculare in CA1 Pyramidal Cells of the Rat Hippocampus In Vitro. | Williams, S. and Lacaille, JC. 1990. Eur J Neurosci. 2: 993-1003. PMID: 12106087
- Baclofen, a GABAB receptor agonist, inhibits human hepatocellular carcinoma cell growth in vitro and in vivo. | Wang, T., et al. 2008. Life Sci. 82: 536-41. PMID: 18222491
- In vivo and in vitro ethanol exposure in prenatal rat brain: GABA(B) receptor modulation on dopamine D(1) receptor and protein kinase A. | Lee, HY., et al. 2008. Synapse. 62: 534-43. PMID: 18435423
- Phaclofen antagonizes post-tetanic disinhibition in the rat dentate gyrus. | Mott, DD., et al. 1990. Neurosci Lett. 110: 131-6. PMID: 2325880
- Phaclofen inhibition of the slow inhibitory postsynaptic potential in hippocampal slice cultures: a possible role for the GABAB-mediated inhibitory postsynaptic potential. | Malouf, AT., et al. 1990. Neuroscience. 35: 53-61. PMID: 2359496
- Baclofen and phaclofen modulate GABA release from slices of rat cerebral cortex and spinal cord but not from retina. | Neal, MJ. and Shah, MA. 1989. Br J Pharmacol. 98: 105-12. PMID: 2804540
- Phaclofen antagonizes the depressant effect of baclofen on spinal reflex transmission in rats. | Wüllner, U., et al. 1989. Brain Res. 496: 341-4. PMID: 2804645
- A physiological role for GABAB receptors in the central nervous system. | Dutar, P. and Nicoll, RA. 1988. Nature. 332: 156-8. PMID: 2831457
- The GABAB antagonist phaclofen inhibits the late K+-dependent IPSP in cat and rat thalamic and hippocampal neurones. | Soltesz, I., et al. 1988. Brain Res. 448: 351-4. PMID: 2837311
- Phaclofen: a peripheral and central baclofen antagonist. | Kerr, DI., et al. 1987. Brain Res. 405: 150-4. PMID: 3032346
- Comparison of antagonism by phaclofen of baclofen induced hyperpolarizations and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons. | Hasuo, H. and Gallagher, JP. 1988. Neurosci Lett. 86: 77-81. PMID: 3362432
- Effects of taurine on depolarization-evoked release of amino acids from rat cortical synaptosomes. | Kamisaki, Y., et al. 1993. Brain Res. 627: 181-5. PMID: 7905350
- gamma-Aminobutyric acid (GABA) autoreceptors in rat cerebral cortex and spinal cord represent pharmacologically distinct subtypes of the GABAB receptor. | Bonanno, G. and Raiteri, M. 1993. J Pharmacol Exp Ther. 265: 765-70. PMID: 8388458
Substrate of:
GABA Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Phaclofen, 5 mg | sc-200462 | 5 mg | $156.00 | |||
Phaclofen, 25 mg | sc-200462A | 25 mg | $468.00 |