Molecular structure of PH-797804, CAS Number: 586379-66-0
PH-797804 (CAS 586379-66-0)
Application:
PH-797804 is a novel pyridinone inhibitor to p38α with IC50 of 26 nM
CAS Number:
586379-66-0
Purity:
≥99%
Molecular Weight:
477.30
Molecular Formula:
C22H19BrF2N2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PH-797804 is a novel pyridinone inhibitor to p38alpha with IC50 of 26 nM. PH-797804 blocks inflammation-induced production of cytokines. It is a member of benzamides, an organofluorine compound, a pyridone, an organobromine compound and an aromatic ether.
PH-797804 (CAS 586379-66-0) References
- Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804. | Xing, L., et al. 2009. Biochemistry. 48: 6402-11. PMID: 19496616
- Discovery of PH-797804, a highly selective and potent inhibitor of p38 MAP kinase. | Selness, SR., et al. 2011. Bioorg Med Chem Lett. 21: 4066-71. PMID: 21641211
- Discovery and characterization of atropisomer PH-797804, a p38 MAP kinase inhibitor, as a clinical drug candidate. | Xing, L., et al. 2012. ChemMedChem. 7: 273-80. PMID: 22174080
- Efficacy and safety of the oral p38 inhibitor PH-797804 in chronic obstructive pulmonary disease: a randomised clinical trial. | MacNee, W., et al. 2013. Thorax. 68: 738-45. PMID: 23539534
- Development of a validated UPLC-MS/MS method for quantification of p38 MAPK inhibitor PH-797804: Application to a pharmacokinetic study in rat plasma. | Qu, J., et al. 2019. J Chromatogr B Analyt Technol Biomed Life Sci. 1134-1135: 121877. PMID: 31785533
- Elevated p38MAPK activity promotes neural stem cell aging. | Moreno-Cugnon, L., et al. 2020. Aging (Albany NY). 12: 6030-6036. PMID: 32243258
- In vitro P38MAPK inhibition in aged astrocytes decreases reactive astrocytes, inflammation and increases nutritive capacity after oxygen-glucose deprivation. | Revuelta, M., et al. 2021. Aging (Albany NY). 13: 6346-6358. PMID: 33563843
- Senescence Alterations in Pulmonary Hypertension. | Roger, I., et al. 2021. Cells. 10: PMID: 34943963
- Chondrocyte apoptosis in temporomandibular joint osteoarthritis promotes bone resorption by enhancing chemotaxis of osteoclast precursors. | Guo, YN., et al. 2022. Osteoarthritis Cartilage. 30: 1140-1153. PMID: 35513247
- Endothelin-1 alters BMP signaling to promote proliferation of pulmonary artery smooth muscle cells. | Maruyama, H., et al. 2022. Can J Physiol Pharmacol. 100: 1018-1027. PMID: 36037530
- Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier. | Faist, A., et al. 2023. Antiviral Res. 209: 105475. PMID: 36423831
- Synthesis and Biological Activity of a VHL-Based PROTAC Specific for p38α. | Cubillos-Rojas, M., et al. 2023. Cancers (Basel). 15: PMID: 36765568
Inhibitor of:
MEK-3, MEK3, p38, p38 alpha, p38γ MAPK12, Pbs2, RELL2, and Ser/Thr Protein Kinase.Activator of:
p38γ.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PH-797804, 5 mg | sc-364579 | 5 mg | $92.00 | |||
PH-797804, 50 mg | sc-364579A | 50 mg | $520.00 | |||
PH-797804, 500 mg | sc-364579B | 500 mg | $2601.00 |