Molecular structure of PGPC, CAS Number: 89947-79-5
PGPC (CAS 89947-79-5)
Alternate Names:
1-palmitoyl-2-glutaryl phosphatidylcholine
Application:
PGPC is a potent PPARγ agonist
CAS Number:
89947-79-5
Molecular Weight:
609.7
Molecular Formula:
C29H56NO10P
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
PGPC serves as a vital redox cofactor within the mitochondria′s electron transport chain, playing a role in the conversion of energy from carbohydrates, fats, and proteins. It also assumes the role of an antioxidant, safeguarding cells against free radicals and averting oxidative harm. Furthermore, PGPC exhibits the ability to regulate the expression of diverse genes associated with inflammation control, while stimulating the generation of nerve growth factor, a component in neuron growth and restoration.
PGPC (CAS 89947-79-5) References
- Structurally similar oxidized phospholipids differentially regulate endothelial binding of monocytes and neutrophils. | Leitinger, N., et al. 1999. Proc Natl Acad Sci U S A. 96: 12010-5. PMID: 10518567
- Studies of phospholipid oxidation by electrospray mass spectrometry: from analysis in cells to biological effects. | Spickett, CM. and Dever, G. 2005. Biofactors. 24: 17-31. PMID: 16403960
- The oxidized phospholipids POVPC and PGPC inhibit growth and induce apoptosis in vascular smooth muscle cells. | Fruhwirth, GO., et al. 2006. Biochim Biophys Acta. 1761: 1060-9. PMID: 16904371
- Toxicity of oxidized phospholipids in cultured macrophages. | Stemmer, U., et al. 2012. Lipids Health Dis. 11: 110. PMID: 22958747
- Fragmented oxidation products define barrier disruptive endothelial cell response to OxPAPC. | Birukova, AA., et al. 2013. Transl Res. 161: 495-504. PMID: 23305708
- Suppression of Toll-like receptor 4 activation by endogenous oxidized phosphatidylcholine, KOdiA-PC by inhibiting LPS binding to MD2. | Kim, MJ., et al. 2013. Inflamm Res. 62: 571-80. PMID: 23474920
- Inhibition of monocyte chemotaxis by VB-201, a small molecule lecinoxoid, hinders atherosclerosis development in ApoE⁻/⁻ mice. | Feige, E., et al. 2013. Atherosclerosis. 229: 430-9. PMID: 23880199
- Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice. | Jové, M., et al. 2014. Aging Cell. 13: 828-37. PMID: 25052291
- Plasma lipidomics discloses metabolic syndrome with a specific HDL phenotype. | Jové, M., et al. 2014. FASEB J. 28: 5163-71. PMID: 25169057
- Comprehensive MS/MS profiling by UHPLC-ESI-QTOF-MS/MS using SWATH data-independent acquisition for the study of platelet lipidomes in coronary artery disease. | Schlotterbeck, J., et al. 2019. Anal Chim Acta. 1046: 1-15. PMID: 30482286
- Distribution of plasma oxidised phosphatidylcholines in chronic kidney disease and periodontitis as a co-morbidity. | Ademowo, OS., et al. 2020. Free Radic Biol Med. 146: 130-138. PMID: 31644951
- Allergen inhalation generates pro-inflammatory oxidised phosphatidylcholine associated with airway dysfunction. | Pascoe, CD., et al. 2021. Eur Respir J. 57: PMID: 32883680
- Interferon-Independent Restriction of RNA Virus Entry and Replication by a Class of Damage-Associated Molecular Patterns. | Ernandes, MJ. and Kagan, JC. 2021. mBio. 12: PMID: 33849978
- CB1 R and iNOS are distinct players promoting pulmonary fibrosis in Hermansky-Pudlak syndrome. | Cinar, R., et al. 2021. Clin Transl Med. 11: e471. PMID: 34323400
- Chronic and Binge Alcohol Ingestion Increases Truncated Oxidized Phosphatidylcholines in Mice Lungs Due to Increased Oxidative Stress. | Appolonia, CN., et al. 2022. Front Physiol. 13: 860449. PMID: 35685280
Activator of:
PPAR gamma.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PGPC, 500 µg | sc-205432 | 500 µg | $34.00 | |||
PGPC, 1 mg | sc-205432A | 1 mg | $45.00 |