PGM 3 Antibody (D-4): sc-390239

PGM 3 Antibody (D-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects PGM 3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PGM 3 (D-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. PGM 3, a member of the phosphoglucomutase family, plays a crucial role in carbohydrate metabolism, specifically in the interconversion of glucose-1-phosphate and glucose-6-phosphate, which is vital for both glycogenolysis and glycogenesis. This enzymatic activity is essential for maintaining glucose homeostasis and energy production in cells, particularly in tissues with high metabolic demands such as the heart, liver, and pancreas. PGM 3 is a 542 amino acid protein expressed ubiquitously, with highest levels found in heart, liver, pancreas, and placenta tissues, while being absent in lung tissue. PGM 3 operates as a monomer and requires a magnesium ion for catalytic activity, highlighting the importance of metal ion cofactors in enzymatic reactions. Understanding PGM 3 function and regulation is critical for elucidating metabolic disorders related to glycogen storage and energy metabolism.

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PGM 3 Antibody (D-4) References:

1. Identification of human phosphoglucomutase 3 (PGM3) as N-acetylglucosamine-phosphate mutase (AGM1).  |  Pang, H., et al. 2002. Ann Hum Genet. 66: 139-44. PMID: 12174217
2. Phosphoglucomutase 1: complete human and rabbit mRNA sequences and direct mapping of this highly polymorphic marker on human chromosome 1.  |  Whitehouse, DB., et al. 1992. Proc Natl Acad Sci U S A. 89: 411-5. PMID: 1530890
3. Cloning and characterization of the phosphoglucomutase of Trypanosoma cruzi and functional complementation of a Saccharomyces cerevisiae PGM null mutant.  |  Penha, LL., et al. 2005. Glycobiology. 15: 1359-67. PMID: 16037487
4. Streptococcus iniae phosphoglucomutase is a virulence factor and a target for vaccine development.  |  Buchanan, JT., et al. 2005. Infect Immun. 73: 6935-44. PMID: 16177373
5. Overexpression of Mycobacterium tuberculosis manB, a phosphomannomutase that increases phosphatidylinositol mannoside biosynthesis in Mycobacterium smegmatis and mycobacterial association with human macrophages.  |  McCarthy, TR., et al. 2005. Mol Microbiol. 58: 774-90. PMID: 16238626
6. Lithium induces phosphoglucomutase activity in various tissues of rats and in bipolar patients.  |  Csutora, P., et al. 2006. Int J Neuropsychopharmacol. 9: 613-9. PMID: 16259646
7. Increased phosphoglucomutase activity suppresses the galactose growth defect associated with elevated levels of Ras signaling in S. cerevisiae.  |  Howard, SC., et al. 2006. Curr Genet. 49: 1-6. PMID: 16292676
8. Linkage and association studies of two phosphoglucomutase loci (PGM1 and PGM3) to eighteen other markers. Analysis of the segregation at the marker loci.  |  Lamm, LU., et al. 1970. Hum Hered. 20: 305-18. PMID: 4099123
9. A phylogeny for the principal alleles of the human phosphoglucomutase-1 locus.  |  Takahashi, N., et al. 1982. Proc Natl Acad Sci U S A. 79: 6636-40. PMID: 6216484

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PGM 3 Antibody (D-4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-PGM 3 Antibody (D-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PGM 3 Antibody (D-4) Specifications

Alternate Product Name: PGM 3

Product Clone Name: D-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 243-542

Epitope Target: PGM 3

Epitope Species: human

Product Reactivity/Detection: PGM 3

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for PGM 3 Antibody (D-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin