Molecular structure of PGH2 (Prostaglandin H2), 500 µg/ml, CAS Number: 42935-17-1
PGH2 (Prostaglandin H2), 500 µg/mL (CAS 42935-17-1)
Alternate Names:
9α,11α-epidioxy-15S-hydroxy-prosta-5Z,13E-dien-1-oic acid
CAS Number:
42935-17-1
Molecular Weight:
352.50
Molecular Formula:
C20H32O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
PGH2 (Prostaglandin H2), 500 µg/mL, a precursor for the 2-series thromboxanes and prostaglandins, is a potent platelet aggregator of vascular smooth muscle contraction. PGH2 is also an inhibitor of platelet TXA synthase (thromboxane synthase). In the rabbit pulmonary artery, PGH2 activated the stretch induced contraction of rabbit pulmonary artery. At an IC50 at 10-25 ng/ml in the isolated rat fat cell, PGH2 inhibited the accumulation of noradrenaline induced cyclic AMP.
PGH2 (Prostaglandin H2), 500 µg/mL (CAS 42935-17-1) References
- Down-regulation of cyclooxygenase product generation by human peritoneal macrophages. | Mackenzie, R., et al. 1992. Immunology. 76: 648-54. PMID: 1328041
- Selective inhibition of prostacyclin synthase activity by rofecoxib. | Griffoni, C., et al. 2007. J Cell Mol Med. 11: 327-38. PMID: 17488481
- Cyclic adenosine 3',5'-monophosphate inhibits the availability of arachidonate to prostaglandin synthetase in human platelet suspensions. | Minkes, M., et al. 1977. J Clin Invest. 59: 449-54. PMID: 190267
- High-precision, room temperature screening assay for inhibitors of microsomal prostaglandin E synthase-1. | Andersson, S., et al. 2012. J Biomol Screen. 17: 1372-8. PMID: 22895459
- Sulforaphane inhibits prostaglandin E2 synthesis by suppressing microsomal prostaglandin E synthase 1. | Zhou, J., et al. 2012. PLoS One. 7: e49744. PMID: 23166763
- Candida parapsilosis produces prostaglandins from exogenous arachidonic acid and OLE2 is not required for their synthesis. | Grózer, Z., et al. 2015. Virulence. 6: 85-92. PMID: 25654274
- A role for trypanosomatid aldo-keto reductases in methylglyoxal, prostaglandin and isoprostane metabolism. | Roberts, AJ., et al. 2018. Biochem J. 475: 2593-2610. PMID: 30045874
- The action of prostanoid receptor agonists and antagonists on smooth muscle and platelets. | Eglen, RM. and Whiting, RL. 1988. Br J Pharmacol. 94: 591-601. PMID: 3134971
- PTGS1 gene variations associated with bleeding and platelet dysfunction. | Palma-Barqueros, V., et al. 2021. Platelets. 32: 710-716. PMID: 32584621
- Discovery and Development of a Novel mPGES-1/5-LOX Dual Inhibitor LFA-9 for Prevention and Treatment of Chronic Inflammatory Diseases. | Yarla, NS., et al. 2020. J Inflamm Res. 13: 1261-1278. PMID: 33408499
- Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation. | Hamberg, M., et al. 1974. Proc Natl Acad Sci U S A. 71: 345-9. PMID: 4521806
- Bromoacetamido analogs of indomethacin and mefenamic acid as affinity-labeling agents and mechanistic probes for prostaglandin H2 synthase. | Tang, MS., et al. 1995. Biochemistry. 34: 808-15. PMID: 7827039
- Expression and role of cyclooxygenase isoforms in alveolar and peritoneal macrophages. | Wilborn, J., et al. 1995. Am J Physiol. 268: L294-301. PMID: 7864149
- Role of prostaglandin H2 as an endothelium-derived contracting factor in diabetic state. | Shimizu, K., et al. 1993. Diabetes. 42: 1246-52. PMID: 8349035
- Thromboxane A2 analogue U 46619 enhances tumour cell proliferation in HeLa cells via specific receptors which are apparently distinct from TXA2 receptors on human platelets. | Nigam, S., et al. 1993. FEBS Lett. 316: 99-102. PMID: 8422945
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PGH2 (Prostaglandin H2), 500 µg/mL, 50 µg | sc-506662 | 50 µg | $105.00 | |||
PGH2 (Prostaglandin H2), 500 µg/mL, 1 mg | sc-506662A | 1 mg | $1499.00 | |||
PGH2 (Prostaglandin H2), 500 µg/mL, 3 mg | sc-506662B | 3 mg | $3119.00 |