Molecular structure of PGH2 (Prostaglandin H2), 1 mg/500 µl, CAS Number: 42935-17-1
PGH2 (Prostaglandin H2), 1 mg/500 µl (CAS 42935-17-1)
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Application:
PGH2 (Prostaglandin H2), 1 mg/500 µl is a thromboxane A2 precursor and a platelet aggregator of vascular smooth muscle contraction
CAS Number:
42935-17-1
Purity:
95%
Molecular Weight:
352.50
Molecular Formula:
C20H32O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PGH2 (Prostaglandin H2), 1 mg/500 µl is a critical intermediate in the biosynthesis of various prostaglandins and thromboxanes, which are compounds involved in numerous physiological processes. In research, PGH2 (Prostaglandin H2), 1 mg/500 µl is studied for its role in the arachidonic acid pathway, where it is synthesized from arachidonic acid by the action of cyclooxygenase enzymes. This pathway is of significant interest in understanding the inflammatory response, as well as the regulation of platelet aggregation and vascular tone. Researchers also utilize PGH2 (Prostaglandin H2), 1 mg/500 µl to investigate the specificity and mechanisms of action of cyclooxygenase isozymes. Additionally, PGH2 (Prostaglandin H2), 1 mg/500 µl is instrumental in the study of signal transduction pathways where its downstream metabolites play a role as local hormones or autacoids.
PGH2 (Prostaglandin H2), 1 mg/500 µl (CAS 42935-17-1) References
- Mesangial cells release untransformed prostaglandin H2 as a major prostanoid. | Soler, M., et al. 2001. Kidney Int. 59: 1283-9. PMID: 11260389
- Prostaglandin H2 (PGH2) accelerates formation of amyloid beta1-42 oligomers. | Boutaud, O., et al. 2002. J Neurochem. 82: 1003-6. PMID: 12358806
- Endothelium-derived prostaglandin H2 evokes the stretch-induced contraction of rabbit pulmonary artery. | Saito, M., et al. 2003. Eur J Pharmacol. 467: 151-61. PMID: 12706469
- Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing bimatoprost. | Komoto, J., et al. 2006. Biochemistry. 45: 1987-96. PMID: 16475787
- Paracetamol (Acetaminophen): mechanisms of action. | Anderson, BJ. 2008. Paediatr Anaesth. 18: 915-21. PMID: 18811827
- Mutation of a critical arginine in microsomal prostaglandin E synthase-1 shifts the isomerase activity to a reductase activity that converts prostaglandin H2 into prostaglandin F2alpha. | Hammarberg, T., et al. 2009. J Biol Chem. 284: 301-305. PMID: 18984580
- Comparison of PGH2 binding site in prostaglandin synthases. | Paragi-Vedanthi, P. and Doble, M. 2010. BMC Bioinformatics. 11 Suppl 1: S51. PMID: 20122226
- The affinities of prostaglandin H2 and thromboxane A2 for their receptor are similar in washed human platelets. | Mayeux, PR., et al. 1988. Biochem Biophys Res Commun. 157: 733-9. PMID: 2974286
- Biochemical and immunological demonstration of prostaglandin D2, E2, and F2 alpha formation from prostaglandin H2 by various rat glutathione S-transferase isozymes. | Ujihara, M., et al. 1988. Arch Biochem Biophys. 264: 428-37. PMID: 3041912
- Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation. | Hamberg, M., et al. 1974. Proc Natl Acad Sci U S A. 71: 345-9. PMID: 4521806
- Prostaglandin H2 directly lowers human platelet cAMP levels. | Rybicki, JP. and Le Breton, GC. 1983. Thromb Res. 30: 407-14. PMID: 6310815
- Endothelium-dependent contractions are associated with both augmented expression of prostaglandin H synthase-1 and hypersensitivity to prostaglandin H2 in the SHR aorta. | Ge, T., et al. 1995. Circ Res. 76: 1003-10. PMID: 7758154
- Prostaglandin B2-induced pulmonary hypertension is mediated by TxA2/PGH2 receptor stimulation. | Liu, F., et al. 1994. Am J Physiol. 267: L602-8. PMID: 7977770
- Thromboxane A2/prostaglandin H2-stimulated mitogenesis of coronary artery smooth muscle cells involves activation of mitogen-activated protein kinase and S6 kinase. | Morinelli, TA., et al. 1994. J Biol Chem. 269: 5693-8. PMID: 8119906
- Preoperative thromboxane A2/prostaglandin H2 receptor activity predicts early graft thrombosis. | Brothers, TE., et al. 1998. J Vasc Surg. 27: 317-25; discussion 326-8. PMID: 9510286
Inhibitor of:
TXA Synthase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PGH2 (Prostaglandin H2), 1 mg/500 µl, 50 µg | sc-201266 | 50 µg | $110.00 | |||
PGH2 (Prostaglandin H2), 1 mg/500 µl, 1 mg | sc-201266A | 1 mg | $1399.00 | |||
PGH2 (Prostaglandin H2), 1 mg/500 µl, 3 mg | sc-201266B | 3 mg | $3499.00 | |||
PGH2 (Prostaglandin H2), 1 mg/500 µl, 5 mg | sc-201266C | 5 mg | $5815.00 | |||
PGH2 (Prostaglandin H2), 1 mg/500 µl, 10 mg | sc-201266D | 10 mg | $11220.00 |