PGF2α (Prostaglandin F2α) CAS: 38562-01-5
MF: C20H33O5·C4H12NO3
MW: 475.6
Binds to PGF2Rα, shown to stimulate COX2 expression, and regulate adrenal endocrine function.

PGF2α (Prostaglandin F2α) (CAS 38562-01-5)

PGF2α (Prostaglandin F2α) | CAS 38562-01-5 is rated 5.0 out of 5 by 1.
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Alternate Names: Prostaglandin F tromethamine salt;Dinoprost Tromethamine
Application: PGF2α (Prostaglandin F2α) is binds to PGF2Rα, shown to stimulate COX2 expression, and regulate adrenal endocrine function
CAS Number: 38562-01-5
Purity: ≥99%
Molecular Weight: 475.6
Molecular Formula: C20H33O5·C4H12NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PGF (Prostaglandin F) is a major uterine luteolytic prostaglandin, that is an endogenous agonist of PGF2Rα (FP receptor; KD=1.0 nM). This product has been shown to inhibit differentiation of mouse 3T3-L1 preadipocytes, promote neutrophil chemotaxis via the chemokine CXCL1 in endometrial adenocarcinoma cells, stimulate COX2 mRNA expression and thereby PGF synthesis through NF-κB activation via reactive oxygen species (ROS) in the corpus luteum of pseudopregnant rats, and regulate adrenal endocrine function. PGF is synthesized from PGE2 (sc-201225), both of which are synthesized from the same precursor, PGH2 (sc-201266). The diverse activity displayed by PGF, other prostaglandins, and analogous molecules, makes this product an extremely useful research tool.


References

1. Vincent, D.L., et al. 1986. Prostaglandins. 31: 715-733. PMID: 3460114
2. Abramovitz, M., et al. 1994. J. Biol. Chem. 269: 2632-2636. PMID: 8300593
3. Miller, C.W., et al. 1996. Endocrinology. 137: 5641-5650. PMID: 8940395
4. Wallace, A.E., et al. 2009. Cancer Res. 69: 5726-5733. PMID: 19549892
5. Lambert-Langlais, S., et al. 2009. PLoS ONE. 4: e7309. PMID: 19809495
6. Yu, Y., et al. 2009. Proc. Natl. Acad. Sci. U.S.A. 106: 7985-7990. PMID: 19416858
7. Taniguchi, K., et al. 2010. Reproduction. PMID: 20826536

Physical State :
Solid
Solubility :
Soluble in water (1 mg/ml), ethanol (~50 mg/ml), PBS (25 mg/ml), DMSO (~50 mg/ml), DMF (~50 mg/ml), and methanol.
Storage :
Store at -20° C
IC50 :
High-affinity choline transporter: IC50 = 2.77 µM (human)
pK Values :
pKa: 4.76
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UK8025000
PubChem CID :
5282415
Merck Index :
14: 7878
MDL Number :
MFCD00077863
EC Number :
254-002-3
Beilstein Registry :
4087514
SMILES :
CCCCC[[email protected]@H](/C=C/[[email protected]]1[[email protected]@H](C[[email protected]@H]([[email protected]@H]1C/C=C\\CCCC(=O)O)O)O)O.C(C(CO)(CO)N)O

Download SDS (MSDS)

Certificate of Analysis

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PGF2α (Prostaglandin F2α) (CAS 38562-01-5)  Product Citations

See how others have used PGF2α (Prostaglandin F2α) (CAS 38562-01-5). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 25173977  Jin, D. et al. 2014. Nature cell biology. 16: 841-51.

PMID: # 4677341  Douglas, RH. et al. 1972. Prostaglandins. 2: 265-268.

PMID: # 5723367  Karim, SM. et al. 1968. Br Med J. 4: 621-623.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Karim et al Karim et al. (PubMed ID 5723367) used PGF2 (Prostaglandin F2 ) to induce labor in women near term. -SCBT Publication Review
Date published: 2015-01-21
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