Molecular structure of PGF2α (Prostaglandin F2α), CAS Number: 38562-01-5
PGF2α (Prostaglandin F2α) (CAS 38562-01-5)
See product citations (5)
Alternate Names:
Prostaglandin F2α tromethamine salt;Dinoprost Tromethamine
Application:
PGF2α (Prostaglandin F2α) is binds to PGF2Rα, shown to stimulate COX2 expression, and regulate adrenal endocrine function
CAS Number:
38562-01-5
Purity:
≥99%
Molecular Weight:
475.62
Molecular Formula:
C20H34O5•C4H11NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PGF2α (Prostaglandin F2α) is a major uterine luteolytic prostaglandin, that is an endogenous agonist of PGF2Rα (FP receptor KD=1.0 nM). This product may act to inhibit differentiation of mouse 3T3-L1 preadipocytes, promote neutrophil chemotaxis via the chemokine CXCL1 in endometrial adenocarcinoma cells, stimulate COX2 mRNA expression and thereby PGF2α (Prostaglandin F2α) synthesis through NF-κB activation via reactive oxygen species (ROS) in the corpus luteum of pseudopregnant rats, and regulate adrenal endocrine function. PGF2α (Prostaglandin F2α) is synthesized from PGE2 (sc-201225), both of which are synthesized from the same precursor, PGH2 (sc-201266). The diverse activity displayed by PGF2α (Prostaglandin F2α), other prostaglandins, and analogous molecules, makes this product an extremely useful research tool.
PGF2α (Prostaglandin F2α) (CAS 38562-01-5) References
- Topical prostaglandin F2alpha treatment reduces collagen types I, III, and IV in the monkey uveoscleral outflow pathway. | Sagara, T., et al. 1999. Arch Ophthalmol. 117: 794-801. PMID: 10369592
- Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis. | Yu, Y., et al. 2009. Proc Natl Acad Sci U S A. 106: 7985-90. PMID: 19416858
- Prostaglandin F2alpha-F-prostanoid receptor signaling promotes neutrophil chemotaxis via chemokine (C-X-C motif) ligand 1 in endometrial adenocarcinoma. | Wallace, AE., et al. 2009. Cancer Res. 69: 5726-33. PMID: 19549892
- Aldo keto reductase 1B7 and prostaglandin F2alpha are regulators of adrenal endocrine functions. | Lambert-Langlais, S., et al. 2009. PLoS One. 4: e7309. PMID: 19809495
- Prostaglandin F2α (PGF2α) stimulates PTGS2 expression and PGF2α synthesis through NFKB activation via reactive oxygen species in the corpus luteum of pseudopregnant rats. | Taniguchi, K., et al. 2010. Reproduction. 140: 885-92. PMID: 20826536
- Olfactory receptor for prostaglandin F2α mediates male fish courtship behavior. | Yabuki, Y., et al. 2016. Nat Neurosci. 19: 897-904. PMID: 27239939
- Intra-ovarian dynamic blood flow in pseudopregnant rabbits during prostaglandin F2α-induced luteolysis. | Troisi, A., et al. 2019. Reprod Domest Anim. 54: 176-183. PMID: 30187583
- Prostaglandin F2α stimulates angiogenesis at the embryo-maternal interface during early pregnancy in the pig. | Kaczynski, P., et al. 2020. Theriogenology. 142: 169-176. PMID: 31600637
- Prostaglandin F2α Induces Goat Corpus Luteum Regression via Endoplasmic Reticulum Stress and Autophagy. | Wen, X., et al. 2020. Front Physiol. 11: 868. PMID: 33013430
- Prostaglandin F2α protects against pericyte apoptosis by inhibiting the PI3K/Akt/GSK3β/β-catenin signaling pathway. | Cheng, Y., et al. 2021. Ann Transl Med. 9: 1021. PMID: 34277821
- Role of progesterone in regulating uteroovarian venous concentrations of PGF2 alpha and PGE2 during the estrous cycle and early pregnancy in ewes. | Vincent, DL. and Inskeep, EK. 1986. Prostaglandins. 31: 715-33. PMID: 3460114
- Response of non-failing hypertrophic rat hearts to prostaglandin F2α. | Krstic, AM., et al. 2020. Curr Res Physiol. 2: 1-11. PMID: 34746811
- Prostaglandin F2α and angiotensin II type 1 receptors exhibit differential cognate G protein coupling regulation. | Sedki, D., et al. 2022. J Biol Chem. 298: 102294. PMID: 35872018
- Cloning and expression of a cDNA for the human prostanoid FP receptor. | Abramovitz, M., et al. 1994. J Biol Chem. 269: 2632-6. PMID: 8300593
- The mechanism of inhibition of 3T3-L1 preadipocyte differentiation by prostaglandin F2alpha. | Miller, CW., et al. 1996. Endocrinology. 137: 5641-50. PMID: 8940395
Activator of:
PGF2alphaR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PGF2α (Prostaglandin F2α), 1 mg | sc-201227 | 1 mg | $41.00 | |||
PGF2α (Prostaglandin F2α), 5 mg | sc-201227B | 5 mg | $165.00 | |||
PGF2α (Prostaglandin F2α), 10 mg | sc-201227A | 10 mg | $294.00 | |||
PGF2α (Prostaglandin F2α), 25 mg | sc-201227C | 25 mg | $651.00 |