Molecular structure of PGA1 (Prostaglandin A1), CAS Number: 14152-28-4
PGA1 (Prostaglandin A1) (CAS 14152-28-4)
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Alternate Names:
PGA1 (Prostaglandin A1) is known as a Cyclopentenone prostaglandin.
Application:
PGA1 (Prostaglandin A1) is a potent anti-inflammatory cyclopentenone prostaglandin demonstrating inhibition of NFκB
CAS Number:
14152-28-4
Purity:
≥98%
Molecular Weight:
336.5
Molecular Formula:
C20H32O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PGA1 (Prostaglandin A1) is an anti-inflammatory cyclopentenone prostaglandin, biosynthesized from dihomo-γ-linolenic acid. PGA1 (Prostaglandin A1) was originally discovered as a dehydration product of PGE1 (sc-201223). PGA1 (Prostaglandin A1) may act to cause renal vasodilation, stimulate renin release, inhibit NFκB activation, activate PPARs, and induce thermotolerance through modulation of heat shock protein 70. Furthermore, PGA1 (Prostaglandin A1) may act to inhibit the proliferation of tumor cells with an IC50 = 7.5 μM for human ovarian cell cultures.
PGA1 (Prostaglandin A1) (CAS 14152-28-4) References
- Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. | Rossi, A., et al. 2000. Nature. 403: 103-8. PMID: 10638762
- Differential effect of prostaglandin A1 in hypertensive patients with low, normal and high renin. | Krakoff, LR., et al. 1975. Clin Sci Mol Med Suppl. 2: 311s-313s. PMID: 1077785
- Growth inhibition of Friend erythroleukaemia cell tumours in vivo by a synthetic analogue of prostaglandin A: an action independent of natural killer-activity. | Marini, S., et al. 1990. Br J Cancer. 61: 394-9. PMID: 2328205
- Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus. | Caldas, LA., et al. 2018. Braz J Microbiol. 49: 785-789. PMID: 29544983
- Immuno-pathogenesis of nCOVID-19 and a possible host-directed therapy including anti-inflammatory and anti-viral prostaglandin (PG J2) for effective treatment and reduction in the death toll. | Shahzad, S. and Willcox, M. 2020. Med Hypotheses. 143: 110080. PMID: 32683221
- Activation of phospholipase A2 by prostaglandin in vitro. | Code, C., et al. 2021. Prostaglandins Other Lipid Mediat. 152: 106500. PMID: 33038487
- Prostaglandin A1 Decreases the Phosphorylation of Tau by Activating Protein Phosphatase 2A via a Michael Addition Mechanism at Cysteine 377. | Xu, GB., et al. 2021. Mol Neurobiol. 58: 1114-1127. PMID: 33095414
- A biolabel research based on metabonomics reveals the therapeutic potentials of Herba Lysimachiae in synovial diseases: The dual effects on synovial platelet aggregation by prostaglandin E1/E2. | Li, XZ., et al. 2021. J Chromatogr B Analyt Technol Biomed Life Sci. 1174: 122726. PMID: 33957357
- Prostaglandins in human seminal plasma. Prostaglandins and related factors 46. | Hamberg, M. and Samuelsson, B. 1966. J Biol Chem. 241: 257-63. PMID: 5903721
- Induction of renin release by exogenous prostaglandins in hyporeninemic hypoaldosteronism. | Hahn, J., et al. 1980. Prostaglandins. 20: 15-23. PMID: 6996036
- Differential activation of peroxisome proliferator-activated receptors by eicosanoids. | Yu, K., et al. 1995. J Biol Chem. 270: 23975-83. PMID: 7592593
- Preclinical studies of antitumor prostaglandins by using human ovarian cancer cells. | Kikuchi, Y., et al. 1994. Cancer Metastasis Rev. 13: 309-15. PMID: 7712593
- Induction of thermotolerance by prostaglandin A in human cells. | Amici, C., et al. 1993. Exp Cell Res. 207: 230-4. PMID: 8344376
- Modulation of prostaglandin A1-induced thermotolerance by quercetin in human leukemic cells: role of heat shock protein 70. | Elia, G., et al. 1996. Cancer Res. 56: 210-7. PMID: 8548766
- Inhibition of nuclear factor kappa B by prostaglandin A1: an effect associated with heat shock transcription factor activation. | Rossi, A., et al. 1997. Proc Natl Acad Sci U S A. 94: 746-50. PMID: 9012856
Inhibitor of:
α-1-Microglobulin.Activator of:
PPAR, and PSMD11.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PGA1 (Prostaglandin A1), 1 mg | sc-201213 | 1 mg | $62.00 | |||
PGA1 (Prostaglandin A1), 10 mg | sc-201213A | 10 mg | $340.00 |