Molecular structure of PF-8380, CAS Number: 1144035-53-9
PF-8380 (CAS 1144035-53-9)
Alternate Names:
6-(3-(piperazin-1-yl)propanoyl)benzo(d)oxazol-2(3H)-one
Application:
PF-8380 is a substrate competitive and tight-binding inhibitor of autotaxin
CAS Number:
1144035-53-9
Molecular Weight:
478.33
Molecular Formula:
C22H21Cl2N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
PF-8380 is a substrate competitive and tight-binding inhibitor of autotaxin.
PF-8380 (CAS 1144035-53-9) References
- A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation. | Gierse, J., et al. 2010. J Pharmacol Exp Ther. 334: 310-7. PMID: 20392816
- PF-8380 and closely related analogs: synthesis and structure-activity relationship towards autotaxin inhibition and glioma cell viability. | St-Cœur, PD., et al. 2013. Arch Pharm (Weinheim). 346: 91-7. PMID: 23300119
- Autotaxin Inhibition with PF-8380 Enhances the Radiosensitivity of Human and Murine Glioblastoma Cell Lines. | Bhave, SR., et al. 2013. Front Oncol. 3: 236. PMID: 24062988
- Development of autotaxin inhibitors: A series of zinc binding triazoles. | Thomson, CG., et al. 2018. Bioorg Med Chem Lett. 28: 2279-2284. PMID: 29798825
- Autotaxin in ascites promotes peritoneal dissemination in pancreatic cancer. | Jinno, N., et al. 2021. Cancer Sci. 112: 668-678. PMID: 33053268
- An updated patent review of autotaxin inhibitors (2017-present). | Tan, Z., et al. 2021. Expert Opin Ther Pat. 31: 421-434. PMID: 33342311
- Targeting autotaxin impacts disease advance in the SOD1-G93A mouse model of amyotrophic lateral sclerosis. | Gento-Caro, Á., et al. 2022. Brain Pathol. 32: e13022. PMID: 34585475
- Nucleotide pyrophosphatase/phosphodiesterases (NPPs) including NPP1 and NPP2/ ATX as important drug targets: A patent review (2015-2020). | Bano, S., et al. 2022. Expert Opin Ther Pat. 32: 743-751. PMID: 35333684
- Design, synthesis and promising anti-tumor efficacy of novel imidazo[1,2-a]pyridine derivatives as potent autotaxin allosteric inhibitors. | Lei, H., et al. 2022. Eur J Med Chem. 236: 114307. PMID: 35436669
- Hybrid imidazo[1,2-a]pyridine analogs as potent ATX inhibitors with concrete in vivo antifibrosis effect. | Li, T., et al. 2022. Arch Pharm (Weinheim). 355: e2200171. PMID: 35661405
Inhibitor of:
Autotaxin, DDC, and EP2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PF-8380, 10 mg | sc-364667 | 10 mg | $207.00 |