Molecular structure of PF 3845, CAS Number: 1196109-52-0
PF 3845 (CAS 1196109-52-0)
Alternate Names:
N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide
Application:
PF 3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor
CAS Number:
1196109-52-0
Molecular Weight:
456.46
Molecular Formula:
C24H23F3N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PF-3845 is a selective and irreversible inhibitor of fatty acid amide hydrolase (FAAH). By inhibiting FAAH, which is responsible for the degradation of N-acyl ethanolamines (NAEs), including the endocannabinoid arachidonoyl ethanolamide (AEA), PF-3845 leads to prolonged elevation of AEA levels in the brain and plasma. The potent binding of PF-3845 to FAAH occurs at Ser241 in the catalytic site, facilitating the sustained increase of AEA. It is suggested to function by carbamylating FAAH′s serine nucleophile.
PF 3845 (CAS 1196109-52-0) References
- Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. | Ahn, K., et al. 2009. Chem Biol. 16: 411-20. PMID: 19389627
- The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice. | Booker, L., et al. 2012. Br J Pharmacol. 165: 2485-96. PMID: 21506952
- The fatty acid amide hydrolase inhibitor PF-3845 promotes neuronal survival, attenuates inflammation and improves functional recovery in mice with traumatic brain injury. | Tchantchou, F., et al. 2014. Neuropharmacology. 85: 427-39. PMID: 24937045
- Interference with acute nausea and anticipatory nausea in rats by fatty acid amide hydrolase (FAAH) inhibition through a PPARα and CB1 receptor mechanism, respectively: a double dissociation. | Rock, EM., et al. 2015. Psychopharmacology (Berl). 232: 3841-8. PMID: 26297326
- Fatty acid amide hydrolase (FAAH) inhibitor PF-3845 reduces viability, migration and invasiveness of human colon adenocarcinoma Colo-205 cell line: an in vitro study. | Wasilewski, A., et al. 2017. Acta Biochim Pol. 64: 519-525. PMID: 28850633
- Inhibition of Fatty Acid Amide Hydrolase by PF-3845 Alleviates the Nitrergic and Proinflammatory Response in Rat Hippocampus Following Acute Stress. | Chen, HC., et al. 2018. Int J Neuropsychopharmacol. 21: 786-795. PMID: 29579222
- Therapeutic endocannabinoid augmentation for mood and anxiety disorders: comparative profiling of FAAH, MAGL and dual inhibitors. | Bedse, G., et al. 2018. Transl Psychiatry. 8: 92. PMID: 29695817
- Modulation of mean arterial pressure and diuresis by renomedullary infusion of a selective inhibitor of fatty acid amide hydrolase. | Ahmad, A., et al. 2018. Am J Physiol Renal Physiol. 315: F967-F976. PMID: 29846106
- Diuretic, Natriuretic, and Vasodepressor Activity of a Lipid Fraction Enhanced in Medium of Cultured Mouse Medullary Interstitial Cells by a Selective Fatty Acid Amide Hydrolase Inhibitor. | Daneva, Z., et al. 2019. J Pharmacol Exp Ther. 368: 187-198. PMID: 30530623
- Re-discovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis. | Wang, H., et al. 2021. J Biol Chem.. PMID: 33397709
- PF-3845, a Fatty Acid Amide Hydrolase Inhibitor, Directly Suppresses Osteoclastogenesis through ERK and NF-κB Pathways In Vitro and Alveolar Bone Loss In Vivo. | Ihn, HJ., et al. 2021. Int J Mol Sci. 22: PMID: 33671948
- Rediscovery of PF-3845 as a new chemical scaffold inhibiting phenylalanyl-tRNA synthetase in Mycobacterium tuberculosis. | Wang, H., et al. 2021. J Biol Chem. 296: 100257. PMID: 33837735
- Fatty acid amide hydrolase activity in the dorsal periaqueductal gray attenuates neuropathic pain and associated dysautonomia. | Woyach, V., et al. 2022. Am J Physiol Regul Integr Comp Physiol. 323: R749-R762. PMID: 36154489
- Anxiety associated with palatable food withdrawal is reversed by the selective FAAH inhibitor PF-3845: A regional analysis of the contribution of endocannabinoid signaling machinery. | de Ceglia, M., et al. 2023. Int J Eat Disord. 56: 1098-1113. PMID: 36840536
Inhibitor of:
FAAH.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PF 3845, 100 µg | sc-361287B | 100 µg | $41.00 | |||
PF 3845, 500 µg | sc-361287C | 500 µg | $117.00 | |||
PF 3845, 10 mg | sc-361287 | 10 mg | $230.00 | |||
PF 3845, 50 mg | sc-361287A | 50 mg | $964.00 |