PET112L Antibody (47.1): sc-100970
- PET112L Antibody (47.1) is a mouse monoclonal IgG2a κ PET112L antibody provided at 100 µg/1.0 ml
- raised against recombinant PET112L of human origin
- recommended for detection of PET112L of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PET112L Antibody (47.1). This work is in progress.
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PET112L Antibody (47.1) is a mouse monoclonal IgG2a kappa light chain antibody that detects PET112L protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-PET112L antibody (47.1) is available as the non-conjugated format. PET112L, also known as HSPC199 or Glu-ADT subunit B (glutamyl-tRNA(Gln) amidotransferase subunit B), consists of 557 amino acids and belongs to the GatB/gatE family of proteins, specifically the GatB subfamily. PET112L is crucial for mitochondrial gene translation, which is essential for proper mitochondrial function and energy metabolism. PET112L is localized in the mitochondria, particularly in tissues such as the heart and muscle, where oxidative phosphorylation is highly active. PET112L′s function is vital for energy production, as any disruption in mitochondrial gene expression can lead to metabolic disorders. Notably, PET112L has been found to be overexpressed in recurrent ependymoma, highlighting potential relevance in cancer biology and as a target for therapeutic intervention.
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PET112L Antibody (47.1) References:
- Gene profiling in human periodontal ligament fibroblasts by subtractive hybridization. | Yamamoto, T., et al. 2003. J Dent Res. 82: 641-5. PMID: 12885851
- Crystal structure of human SCO1: implications for redox signaling by a mitochondrial cytochrome c oxidase 'assembly' protein. | Williams, JC., et al. 2005. J Biol Chem. 280: 15202-11. PMID: 15659396
- Transcript profiling of periodontal fibroblasts and osteoblasts. | Lallier, TE., et al. 2005. J Periodontol. 76: 1044-55. PMID: 16018745
- Predicting which children are at risk for ependymoma relapse. | Sowar, K., et al. 2006. J Neurooncol. 78: 41-6. PMID: 16575538
- On the evolution of the tRNA-dependent amidotransferases, GatCAB and GatDE. | Sheppard, K. and Söll, D. 2008. J Mol Biol. 377: 831-44. PMID: 18279892
- Sequence analysis of a 78.6 kb segment of the left end of Saccharomyces cerevisiae chromosome II. | Obermaier, B., et al. 1995. Yeast. 11: 1103-12. PMID: 7502586
- PET112, a Saccharomyces cerevisiae nuclear gene required to maintain rho+ mitochondrial DNA. | Mulero, JJ., et al. 1994. Curr Genet. 25: 299-304. PMID: 8082172
- A nuclear genetic lesion affecting Saccharomyces cerevisiae mitochondrial translation is complemented by a homologous Bacillus gene. | Kim, SI., et al. 1997. J Bacteriol. 179: 5625-7. PMID: 9287027
- Identification and characterization of human cDNAs specific to BCS1, PET112, SCO1, COX15, and COX11, five genes involved in the formation and function of the mitochondrial respiratory chain. | Petruzzella, V., et al. 1998. Genomics. 54: 494-504. PMID: 9878253
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PET112L Antibody (47.1) | sc-100970 | 100 µg/1.0 ml | $333.00 |