Peruvoside (CAS 1182-87-2)
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Peruvoside is a cardiac glycoside prominently featured in biochemical research focused on cardiovascular function and cellular sodium-potassium pump (Na+/K+-ATPase) activity. Researchers leverage peruvoside to study the intricate mechanisms of ion regulation in cardiac muscle cells, as it binds to and inhibits Na+/K+-ATPase, thereby affecting intracellular ion concentration and contributing to increased force of cardiac muscle contractions. In experimental applications, it is used to understand the modulation of cardiac contractility and to dissect the signal transduction pathways influenced by changes in ion gradients. Moreover, peruvoside′s action on Na+/K+-ATPase has implications for studies on intracellular communication and energy metabolism, as the sodium-potassium pump is a vital component for maintaining cellular homeostasis.
Peruvoside (CAS 1182-87-2) References
- Role of catecholamines in the central mechanism of emetic response induced by peruvoside and ouabain in cats. | Gaitondé, BB. and Joglekar, SN. 1975. Br J Pharmacol. 54: 157-62. PMID: 1148505
- [Inhibitory action of peruvoside and neriifolin on Na+, K(+)-ATPase]. | Ye, YX. and Yang, XR. 1990. Zhongguo Yao Li Xue Bao. 11: 491-4. PMID: 1966653
- Interaction of digitalis-like compounds with p-glycoprotein. | Gozalpour, E., et al. 2013. Toxicol Sci. 131: 502-11. PMID: 23104431
- Peruvoside, a Cardiac Glycoside, Induces Primitive Myeloid Leukemia Cell Death. | Feng, Q., et al. 2016. Molecules. 21: 534. PMID: 27110755
- Anti-Tumor Effects of Cardiac Glycosides on Human Lung Cancer Cells and Lung Tumorspheres. | Kaushik, V., et al. 2017. J Cell Physiol. 232: 2497-2507. PMID: 27662422
- Antitumor effects of naturally occurring cardiac glycosides convallatoxin and peruvoside on human ER+ and triple-negative breast cancers. | Kaushik, V., et al. 2017. Cell Death Discov. 3: 17009. PMID: 28250972
- Peruvoside targets apoptosis and autophagy through MAPK Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways in human cancers. | Reddy, D., et al. 2020. Life Sci. 241: 117147. PMID: 31830480
- Investigation of cardiac glycosides from oleander in a human induced pluripotent stem cells derived cardiomyocyte model. | Amend, N., et al. 2021. Toxicol Lett. 350: 261-266. PMID: 34371141
- Peruvoside is a novel Src inhibitor that suppresses NSCLC cell growth and motility by downregulating multiple Src-EGFR-related pathways. | Lai, Y., et al. 2022. Am J Cancer Res. 12: 2576-2593. PMID: 35812056
- Live cell screening identifies glycosides as enhancers of cardiomyocyte cell cycle activity. | Magadum, A., et al. 2022. Front Cardiovasc Med. 9: 901396. PMID: 36225954
- Studies on peruvoside. 2. Relative effectiveness of propranolol, diphenylhydantoin & ajmaline in peruvoside induced tachyarrhythmias in dogs. | Arora, RB. and Sundaresan, PR. 1973. Indian J Exp Biol. 11: 301-5. PMID: 4783381
- Haemodynamic studies with peruvoside in human congestive heart failure. | Bhatia, ML., et al. 1970. Br Med J. 3: 740-3. PMID: 4919553
- The effects of reserpine and propranolol on the therapeutic and toxic effects of peruvoside in the heart-lung preparation and intact dogs. | Arora, RB., et al. 1972. Indian J Med Res. 60: 143-52. PMID: 5029118
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Peruvoside, 10 mg | sc-391272 | 10 mg | $936.00 |