Perphenazine CAS: 58-39-9
MF: C21H26ClN3OS
MW: 403.97
A D2DR inhibitor.
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Perphenazine (CAS 58-39-9)

Perphenazine | CAS 58-39-9 is rated 5.0 out of 5 by 1.
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Application: Perphenazine is a D2DR inhibitor
CAS Number: 58-39-9
Purity: ≥99%
Molecular Weight: 403.97
Molecular Formula: C21H26ClN3OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

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Perphenazine is a D2DR inhibitor which inhibits the glutamate dehydrogenase in vitro. Perphenazine also acts as a α-adrenergic receptor antagonist and σ-receptor agonist. Studies indicate that uncharged Perphenazine is better at forming complexes with cyclodextrins. In addition, Perphenazine forms more stable complexes with cyclodextrins than fluphenazine (sc-205700). Studies show that Perphenazine enhances the expression of CD71 on K562 cells, while at the same time inhibiting the proliferation of these cells.


References

1. Lutka, A. and Prange, W. 2005. Acta Pol Pharm. 62: 419-425. PMID: 16583980
2. Yuan, L.B. and He, Q. 2005. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 30: 288-291. PMID: 16045015

Solubility :
Soluble in Chloroform and Methanol
Storage :
Store at 4° C
Melting Point :
95-98°C (lit.)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
4748
SMILES :
C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO

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Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-208161, is provided as a white to off-white powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-02-10
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Rated 5 out of 5 by from Yuan et al Yuan et al. (PubMed ID 16045015) found that perphenazine promoted the expression of CD71 and increased Hb content in K562 cells, while inhibiting the proliferation of K562 cells. -SCBT Publication Review
Date published: 2015-03-22
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