Molecular structure of Perphenazine, CAS Number: 58-39-9
Perphenazine (CAS 58-39-9)
Application:
Perphenazine is a D2DR inhibitor
CAS Number:
58-39-9
Purity:
≥99%
Molecular Weight:
403.97
Molecular Formula:
C21H26ClN3OS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Perphenazine is a D2DR inhibitor which inhibits the glutamate dehydrogenase in vitro. Perphenazine also acts as a alpha-adrenergic receptor antagonist and sigma-receptor agonist. Studies indicate that uncharged Perphenazine is better at forming complexes with cyclodextrins. In addition, Perphenazine forms more stable complexes with cyclodextrins than fluphenazine (sc-205700). Studies show that Perphenazine enhances the expression of CD71 on K562 cells, while at the same time inhibiting the proliferation of these cells. It acts as an antagonist at multiple neurotransmitter receptors (such as dopamine, serotonin, and histamine receptors) and ion channels (including calcium, potassium, and sodium channels).
Perphenazine (CAS 58-39-9) References
- Quantification of perphenazine in eurasian otter (Lutra lutra lutra) urine samples by gas chromatography-mass spectrometry. | Ventura, R., et al. 2002. J Chromatogr B Analyt Technol Biomed Life Sci. 769: 79-87. PMID: 11936697
- [Differentiation-inducing effects of perphenazine on K562 leukemia cells]. | Yuan, LB. and He, Q. 2005. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 30: 288-91. PMID: 16045015
- Stability and characterization of perphenazine aerosols generated using the capillary aerosol generator. | Li, X., et al. 2005. Int J Pharm. 303: 113-24. PMID: 16139453
- Comparison of the effect of the R2 phenothiazine ring substituent on fluphenazine and perphenazine interactions with cyclodextrins. | Lutka, A. and Prange, W. 2005. Acta Pol Pharm. 62: 419-25. PMID: 16583980
- Pharmacokinetic behaviour of perphenazine in sheep after intramuscular administration of a long-acting formulation. | Pedernera-Romano, C., et al. 2009. J Vet Pharmacol Ther. 32: 306-8. PMID: 19646098
- Efficacy of perphenazine to prevent postoperative nausea and vomiting: a quantitative systematic review. | Schnabel, A., et al. 2010. Eur J Anaesthesiol. 27: 1044-51. PMID: 20739894
- Fast-dissolving sublingual solid dispersion and cyclodextrin complex increase the absorption of perphenazine in rabbits. | Turunen, E., et al. 2011. J Pharm Pharmacol. 63: 19-25. PMID: 21155811
- Perphenazine versus low-potency first-generation antipsychotic drugs for schizophrenia. | Tardy, M., et al. 2014. Cochrane Database Syst Rev. CD009369. PMID: 25290157
- PLGA biodegradable nanoparticles containing perphenazine or chlorpromazine hydrochloride: effect of formulation and release. | Halayqa, M. and Domańska, U. 2014. Int J Mol Sci. 15: 23909-23. PMID: 25535080
- Molecular mobility in the supercooled and glassy states of nizatidine and perphenazine. | Sailaja, U., et al. 2017. Eur J Pharm Sci. 99: 147-151. PMID: 27916696
- Repurposing of antipsychotics perphenazine for the treatment of endometrial cancer. | Chen, Y., et al. 2020. Bioorg Med Chem Lett. 30: 127239. PMID: 32527541
- Adding perphenazine to increase effectiveness of standard glioblastoma chemoirradiation. | Kast, RE. 2020. J BUON. 25: 1676-1686. PMID: 33099901
- Plasma levels of perphenazine (Trilafon) related to development of extrapyramidal side effects. | Hansen, LB., et al. 1981. Psychopharmacology (Berl). 74: 306-9. PMID: 6794071
Inhibitor of:
BDP1, D2DR, DSCR 5, HePTP, I1PP2A, p55 CDC, Placental lactogen I, PP2A-B55-α, PP2A-B55-δ, PP2A-B56-α, PP2A-B56-β, PP2A-B56-γ, PP2A-Cα, PPP2R3A, Protein tyrosine phosphatase receptor (PTPR), PTPδ, PTPκ, PTPψ, PTPρ, PTPDC1, PTPN13LY, PTPN20A, PTPN20B, SH-PTP1, and TPTE.Activator of:
LPPR3, PP1α, PP2A-Aα, PP2A-Aβ, and PP2A-B55-γ.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Perphenazine, 100 mg | sc-208161 | 100 mg | $190.00 |