Peroxin 10 Antibody (Y-2D3): sc-134419

Peroxin 10 Antibody (Y-2D3) is a mouse monoclonal IgG2b kappa light chain antibody that detects Peroxin 10 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Peroxin 10 antibody (Y-2D3) is available as a non-conjugated format. Peroxin 10, also known as RNF69, is a crucial component in peroxisome biogenesis, which are essential organelles involved in various metabolic processes, including breakdown of very long-chain fatty acids and detoxification of hydrogen peroxide. Located in cytoplasm, Peroxin 10 plays a significant role in ubiquitin-proteasome pathway, exhibiting E3 ligase activity that facilitates ubiquitination of target proteins, thereby regulating their degradation and function. This activity is vital for maintaining cellular homeostasis and responding to oxidative stress. Mutations in Peroxin 10 can lead to severe disorders such as Zellweger syndrome and adrenoleukodystrophy, highlighting Peroxin 10′s importance in human health. Additionally, alternative splicing of Peroxin 10 results in two isoforms, which may have distinct functional roles in peroxisome biogenesis and cellular metabolism.

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Peroxin 10 Antibody (Y-2D3) References:

1. PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.  |  Sacksteder, KA., et al. 2000. J Cell Biol. 148: 931-44. PMID: 10704444
2. Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences.  |  Fransen, M., et al. 2001. Mol Cell Biol. 21: 4413-24. PMID: 11390669
3. Pex10p functions as an E3 ligase for the Ubc4p-dependent ubiquitination of Pex5p.  |  Williams, C., et al. 2008. Biochem Biophys Res Commun. 374: 620-4. PMID: 18644345
4. Identification of novel mutations and sequence variation in the Zellweger syndrome spectrum of peroxisome biogenesis disorders.  |  Yik, WY., et al. 2009. Hum Mutat. 30: E467-80. PMID: 19105186
5. A PEX10 defect in a patient with no detectable defect in peroxisome assembly or metabolism in cultured fibroblasts.  |  Steinberg, SJ., et al. 2009. J Inherit Metab Dis. 32: 109-19. PMID: 19127411
6. Identification of PEX10, the gene defective in complementation group 7 of the peroxisome-biogenesis disorders.  |  Warren, DS., et al. 1998. Am J Hum Genet. 63: 347-59. PMID: 9683594
7. Mutations in PEX10 is the cause of Zellweger peroxisome deficiency syndrome of complementation group B.  |  Okumoto, K., et al. 1998. Hum Mol Genet. 7: 1399-405. PMID: 9700193

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Peroxin 10 Antibody (Y-2D3) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Peroxin 10 Antibody (Y-2D3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Peroxin 10 Antibody (Y-2D3) Specifications

Alternate Product Name: Peroxin 10

Product Clone Name: Y-2D3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-327

Epitope Target: Peroxin 10

Epitope Species: human

Product Reactivity/Detection: Peroxin 10

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 50 µg IgG_2b kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Peroxin 10 Antibody (Y-2D3): N/A