Molecular structure of Permethrin, CAS Number: 52645-53-1
Permethrin (CAS 52645-53-1)
Alternate Names:
Permethrin is known as a pyrethroid insecticide.
Application:
Permethrin is a pyrethroid widely used as a pesticide and modulator of voltage-gated sodium channels.
CAS Number:
52645-53-1
Purity:
≥96%
Molecular Weight:
391.30
Molecular Formula:
C21H20Cl2O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Permethrin is a widely-used pesticide of the pyrethroid family. It interacts with voltage-gated Na+ channels and inhibits their natural deactivation, causing the channels to remain open for a long time and destroying equilibrium of the neuronal system. More specifically, Permethrin is known to delay channel deactivation of the NaV1.8 channel expressed in X. laevis oocytes. Pyrethroids such as Permethrin are also thought to interact with GABA receptors and associated pathways. Compared to mammalian sodium channels, Permethrin is at least 100 times more potent against insect sodium channels.
Permethrin (CAS 52645-53-1) References
- Nerve membrane Na+ channels as targets of insecticides. | Narahashi, T. 1992. Trends Pharmacol Sci. 13: 236-41. PMID: 1321523
- Structure-activity relationships for the action of 11 pyrethroid insecticides on rat Na v 1.8 sodium channels expressed in Xenopus oocytes. | Choi, JS. and Soderlund, DM. 2006. Toxicol Appl Pharmacol. 211: 233-44. PMID: 16051293
- Pyrethroid modulation of spontaneous neuronal excitability and neurotransmission in hippocampal neurons in culture. | Meyer, DA., et al. 2008. Neurotoxicology. 29: 213-25. PMID: 18243323
- Biomonitoring and evaluation of permethrin uptake in forestry workers using permethrin-treated tick-proof pants. | Rossbach, B., et al. 2016. J Expo Sci Environ Epidemiol. 26: 95-103. PMID: 25967068
- The Influence of Ambient Temperature on the Susceptibility of Aedes aegypti (Diptera: Culicidae) to the Pyrethroid Insecticide Permethrin. | Whiten, SR. and Peterson, RK. 2016. J Med Entomol. 53: 139-43. PMID: 26477050
- Bioactivity and laundering resistance of five commercially available, factory-treated permethrin-impregnated fabrics for the prevention of mosquito-borne diseases: the need for a standardized testing and licensing procedure. | Faulde, MK., et al. 2016. Parasitol Res. 115: 1573-82. PMID: 26738734
- Persistent gross lipemia and suspected corneal lipidosis following intravenous lipid therapy in a cat with permethrin toxicosis. | Seitz, MA. and Burkitt-Creedon, JM. 2016. J Vet Emerg Crit Care (San Antonio). 26: 804-808. PMID: 26748969
- PBPK modeling of the cis- and trans-permethrin isomers and their major urinary metabolites in rats. | Willemin, ME., et al. 2016. Toxicol Appl Pharmacol. 294: 65-77. PMID: 26802525
- Knock-down and speed of kill of a combination of fipronil and permethrin for the prevention of Ctenocephalides felis flea infestation in dogs. | Halos, L., et al. 2016. Parasit Vectors. 9: 57. PMID: 26830931
- Efficacy of naringenin against permethrin-induced testicular toxicity in rats. | Mostafa, Hel-S., et al. 2016. Int J Exp Pathol. 97: 37-49. PMID: 26867500
- Changes on fecal microbiota in rats exposed to permethrin during postnatal development. | Nasuti, C., et al. 2016. Environ Sci Pollut Res Int. 23: 10930-10937. PMID: 26898931
- Comparative speed of kill after treatment with Simparica™ (sarolaner) and Advantix®(imidacloprid + permethrin) against induced infestations of Dermacentor reticulatus on dogs. | Becskei, C., et al. 2016. Parasit Vectors. 9: 104. PMID: 26911323
- Pyrethroid Insecticides Directly Activate Microglia Through Interaction With Voltage-Gated Sodium Channels. | Hossain, MM., et al. 2017. Toxicol Sci. 155: 112-123. PMID: 27655349
- The pyrethroids permethrin and cyhalothrin are potent inhibitors of the mitochondrial complex I. | Gassner, B., et al. 1997. J Pharmacol Exp Ther. 281: 855-60. PMID: 9152394
- Functional expression of Drosophila para sodium channels. Modulation by the membrane protein TipE and toxin pharmacology. | Warmke, JW., et al. 1997. J Gen Physiol. 110: 119-33. PMID: 9236205
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Permethrin, 10 mg | sc-201319 | 10 mg | $71.00 | |||
Permethrin, 250 mg | sc-201319A | 250 mg | $133.00 | |||
Permethrin, 1 g | sc-201319B | 1 g | $189.00 | |||
Permethrin, 10 g | sc-201319C | 10 g | $933.00 | |||
Permethrin, 25 g | sc-201319D | 25 g | $1499.00 |