Periodic acid CAS: 10450-60-9
MF: H5IO6
MW: 227.94
A cell cytoplasm stain and a strong oxidizing agent.

Periodic acid (CAS 10450-60-9)

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Alternate Names: Pentahydroxy-λ5-iodane oxide
Application: Periodic acid is a cell cytoplasm stain and a strong oxidizing agent
CAS Number: 10450-60-9
Purity: ≥99%
Molecular Weight: 227.94
Molecular Formula: H5IO6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Periodic acid is a compound used to stain the cytoplasm of cells found in the tubular pattern, mucus, and apical surfaces of cells of various lumen and glycoproteins on SDS-PAGE gels. In addition to staining purposes, periodic acid can be used in oxidation reactions converting sulfides into sulfones, catalyzed by chromium(VI) oxide and oxidation reactions converting alcohols to aldehydes and ketones. Periodic acid can also react with the 1,2 glycol linkage of carbohydrates forming aldehydes in tissue sections which can be colored with Schiff bases, thus allowing for the staining of these tissues. Furthermore, studies show that periodic acid is not effective in staining cancer cells in solid nests, which are better stained using Grimelius silver stain.


References

1. McManus, J.F., 1948. Stain Technol. 23: 99-108. PMID: 18867618
2. Xu, L., et al. 2003. J. Org. Chem. 68: 5388-5391. PMID: 12816505
3. Sugihara, A., et al. 2004. Scand. J. Gastroenterol. 39: 795-800. PMID: 15513370
4. Asadolah, K., et al. 2007. Molecules. 12: 958-964. PMID: 17873831
5. Santos, M.C., et al. 2008. Appl. Immunohistochem. Mol. Morphol. 16: 191-195. PMID: 18227721

Appearance :
Crystalline powder and crystalline
Physical State :
Solid
Solubility :
Soluble in Water
Storage :
Desiccate at room temperature
Melting Point :
122° C (lit.)
Boiling Point :
742.90° C (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25289
MDL Number :
MFCD00011344
EC Number :
233-937-0
SMILES :
OI(=O)(O)(O)(O)O

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Certificate of Analysis

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Periodic acid (CAS 10450-60-9) Product Citations

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PMID: # 10859350  Ziyadeh, FN. et al. 2000. Proc. Natl. Acad. Sci. U.S.A. 97: 8015-8020.

Citations 1 to 1 of 1 total
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