Molecular structure of Perindoprilat, CAS Number: 95153-31-4
Perindoprilat (CAS 95153-31-4)
See product citations (4)
Alternate Names:
(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-Carboxybutyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic Acid; [2S-[1[R*(R*)],2α,3aβ,7aβ]]-1-[2-[(1-Carboxybutyl)amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic Acid; S 9780; USP Perindopril Related Compound B
Application:
Perindoprilat is an angiotensin-converting enzyme (ACE) inhibitor
CAS Number:
95153-31-4
Molecular Weight:
340.41
Molecular Formula:
C17H28N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Perindoprilat is an active metabolite of Perindopril (sc-205799), an ACE (angiotensin converting enzyme) inhibitor, which modulates the activity of low density lipoprotein receptor-related protein (LRP). LRP is a multifunctional endocytic receptor, which functions in the turnover of proteases and the degradation of extracellular matrix proteins. It is known that Perindoprilat inhibits the conversion of angiotensin I into angiotensin II, which lowers arteriolar pressure and increases venous capacity.
Perindoprilat (CAS 95153-31-4) References
- Acute anti-ischemic effects of perindoprilat in men with coronary artery disease and their relation with left ventricular function. | Bartels, GL., et al. 1999. Am J Cardiol. 83: 332-6. PMID: 10072218
- Interaction of perindoprilat with human red blood cells. | Piasecka, A., et al. 1999. Scand J Clin Lab Invest. 59: 147-52. PMID: 10353329
- Elimination kinetics of quinaprilat and perindoprilat in hypertensive patients with renal failure on haemodialysis. | Yamada, S., et al. 2003. Biol Pharm Bull. 26: 872-5. PMID: 12808303
- Specific and high affinity binding of perindoprilat, but not of perindopril to blood ACE. | Bree, F., et al. 1992. Int J Clin Pharmacol Ther Toxicol. 30: 325-30. PMID: 1330941
- Effects of the ACE inhibitor, perindoprilat, and of angiotensin II on the transient inward current of guinea pig ventricular myocytes. | Enous, R., et al. 1992. J Cardiovasc Pharmacol. 19: 17-23. PMID: 1375683
- First LC-MS/MS electrospray ionization validated method for the quantification of perindopril and its metabolite perindoprilat in human plasma and its application to bioequivalence study. | Jain, DS., et al. 2006. J Chromatogr B Analyt Technol Biomed Life Sci. 837: 92-100. PMID: 16709467
- Perindoprilat modulates the activity of lipoprotein receptor-related protein in human mesangial cells. | Pawluczyk, IZ., et al. 2008. J Biol Chem. 283: 4588-94. PMID: 18156630
- Effects of perindoprilat on endothelium-dependent relaxations and contractions in isolated blood vessels. | Kerth, PA. and Vanhoutte, PM. 1991. Am J Hypertens. 4: 226S-234S. PMID: 2043312
- Vascular effects of intravenous infusion of the angiotensin converting enzyme inhibitor perindoprilat. | Benetos, A., et al. 1990. J Hypertens. 8: 819-26. PMID: 2172371
- Perindoprilat monohydrate. | Bojarska, J., et al. 2012. Acta Crystallogr C. 68: o443-6. PMID: 23124459
- Perindoprilat changes ANG (1-9) production in renal arteries isolated from young spontaneously hypertensive rats after ANG I incubation. | Wołkow, PP., et al. 2016. Physiol Res. 65: 561-570. PMID: 26988149
- Inhibition of the angiotensin converting enzyme by perindoprilat and release of nitric oxide. | Desta, B., et al. 1995. Am J Hypertens. 8: 1S-6S. PMID: 7544135
- Effect of the angiotensin-converting enzyme inhibitor, perindoprilat, and of angiotensin-II on the transient inward current of rabbit ventricular myocytes. | Enous, R. and Opie, LH. 1994. Cardiovasc Drugs Ther. 8: 647-51. PMID: 7848899
- The effect of haemodialysis on the pharmacokinetics of perindoprilat after long-term perindopril. | Guérin, A., et al. 1993. Eur J Clin Pharmacol. 44: 183-7. PMID: 8453964
- Prevention of hypoxemia-induced renal dysfunction by perindoprilat in the rabbit. | Huet, F., et al. 1997. Life Sci. 61: 2157-65. PMID: 9393935
Inhibitor of:
ACE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Perindoprilat, 5 mg | sc-208160 | 5 mg | $398.00 | |||
Perindoprilat, 10 mg | sc-208160A | 10 mg | $653.00 | |||
Perindoprilat, 10 mg | sc-208160A-CW | 10 mg | $826.00 |