Molecular structure of Perindopril, CAS Number: 82834-16-0
Perindopril (CAS 82834-16-0)
See product citations (1)
Alternate Names:
Perindopril Erbumine
Application:
Perindopril is an ACE inhibitor
CAS Number:
82834-16-0
Purity:
≥95%
Molecular Weight:
441.60
Molecular Formula:
C19H32N2O5•C4H11N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Perindopril is a potent angiotensin converting enzyme (ACE) inhibitor. ACE is also called peptidyl-dipeptidase A and is a zinc metallopeptidase of the gluzincin family. It catalyzes the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor in the renin-angiotensin-aldosterone system (RAAS). The inhibition of ACE leads to reduced angiotensin II levels. Structurally, Perindopril is an alpha-amino acid ester, specifically the ethyl ester of N-{(2S)-1-[(2S,3aS,7aS)-2-carboxyoctahydro-1H-indol-1-yl]-1-oxopropan-2-yl}-L-norvaline. It is also a dicarboxylic acid monoester, an organic heterobicyclic compound, and an ethyl ester. It has an octahydro-indole nucleus in its structure. Perindopril is metabolized into perindoprilat.
Perindopril (CAS 82834-16-0) References
- Specific properties and effect of perindopril in controlling the renin-angiotensin system. | Ferrari, R., et al. 2005. Am J Hypertens. 18: 142S-154S. PMID: 16125051
- Effect of the angiotensin-converting enzyme inhibitor perindopril on 24-hour blood pressure in patients with lacunar infarction: comparison between dippers and non-dippers. | Yamamoto, Y., et al. 2005. Hypertens Res. 28: 571-8. PMID: 16335885
- Perindopril arginine: benefits of a new salt of the ACE inhibitor perindopril. | Telejko, E. 2007. Curr Med Res Opin. 23: 953-60. PMID: 17519062
- Perindopril and ramipril phosphonate analogues as a new class of angiotensin converting enzyme inhibitors. | Gomez, C., et al. 2013. Bioorg Med Chem. 21: 7216-21. PMID: 24095015
- Inhibition of AAA in a rat model by treatment with ACEI perindopril. | Xiong, F., et al. 2014. J Surg Res. 189: 166-73. PMID: 24602481
- Perindopril regulates the inflammatory mediators, NF-κB/TNF-α/IL-6, and apoptosis in cisplatin-induced renal dysfunction. | Shalkami, AS., et al. 2018. Naunyn Schmiedebergs Arch Pharmacol. 391: 1247-1255. PMID: 30066022
- Effects of angiotensin converting enzyme inhibitor, perindopril, on autonomic reflexes. | Ajayi, AA., et al. 1986. Eur J Clin Pharmacol. 30: 177-82. PMID: 3011440
- Perindopril Reduces Arterial Pressure and Does Not Inhibit Exercise-Induced Angiogenesis in Spontaneously Hypertensive Rats. | Miotto, DS., et al. 2021. J Cardiovasc Pharmacol. 77: 519-528. PMID: 33394824
- Protective effects of perindopril against indomethacin-induced gastric mucosal damage through modulation of DDAH-1/ADMA and ACE-2/ANG-(1-7) signaling pathways. | Mohamed, YT., et al. 2022. Drug Chem Toxicol. 45: 2509-2518. PMID: 34384315
- Targeting inflammation and redox aberrations by perindopril attenuates methotrexate-induced intestinal injury in rats: Role of TLR4/NF-κB and c-Fos/c-Jun pro-inflammatory pathways and PPAR-γ/SIRT1 cytoprotective signals. | Sayed, AM., et al. 2022. Chem Biol Interact. 351: 109732. PMID: 34737150
- Advanced chemometric methods as powerful tools for impurity profiling of drug substances and drug products: Application on bisoprolol and perindopril binary mixture. | Hassan, SA., et al. 2022. Spectrochim Acta A Mol Biomol Spectrosc. 267: 120576. PMID: 34774433
- The cardioprotective effects of perindopril in a model of polymicrobial sepsis: The role of radical oxygen species and the inflammation pathway. | Topcu, A., et al. 2022. J Biochem Mol Toxicol. 36: e23080. PMID: 35417068
- Perindopril prevents development of obesity and hypertension in middle aged diet-induced obese rat models of metabolic syndrome. | Connolly, K., et al. 2023. Life Sci. 314: 121291. PMID: 36535403
Inhibitor of:
ACE, Ace3, DGCR14, and Renin Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Perindopril, 100 mg | sc-205799 | 100 mg | $128.00 | |||
Perindopril, 250 mg | sc-205799A | 250 mg | $255.00 | |||
Perindopril, 1 g | sc-205799B | 1 g | $683.00 |