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Perfluorooctanoyl fluoride (CAS 335-66-0)

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Alternate Names:
Pentadecafluorooctanoyl fluoride
CAS Number:
335-66-0
Molecular Weight:
416.06
Molecular Formula:
C8F16O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Perfluorooctanoyl fluoride (PFOF) is a versatile fluorinated compound extensively employed in scientific research. This compound is a clear, odorless, and non-flammable liquid utilized as a reagent in organic synthesis, as well as a lubricant and non-toxic surfactant. In addition, perfluorooctanoyl fluoride serves as an organic solvent for diluting trifluoroacetic acid and deionized water. It can also act as a monomer for the production of fluorinated polymers. By reacting with hydrogen fluoride, sodium carbonate, and chloride, perfluorooctanoyl fluoride forms perfluoroalkyl halide ions, which can be separated through liquid chromatography. This separation process is particularly useful for isolating halides like fluorine, chlorine, bromine, and iodine.


Perfluorooctanoyl fluoride (CAS 335-66-0) References

  1. Polyfluorinated amides as a historical PFCA source by electrochemical fluorination of alkyl sulfonyl fluorides.  |  Jackson, DA. and Mabury, SA. 2013. Environ Sci Technol. 47: 382-9. PMID: 23205559
  2. Electrochemical decomposition of fluorinated wetting agents in plating industry waste water.  |  Fath, A., et al. 2016. Water Sci Technol. 73: 1659-66. PMID: 27054738
  3. Fluorinated Oligoethylenimine Nanoassemblies for Efficient siRNA-Mediated Gene Silencing in Serum-Containing Media by Effective Endosomal Escape.  |  Zhang, T., et al. 2018. Nano Lett. 18: 6301-6311. PMID: 30240228
  4. Preparation of Superhydrophobic Metal-Organic Framework/Polymer Composites as Stable and Efficient Catalysts.  |  Zhang, B., et al. 2021. ACS Appl Mater Interfaces. 13: 32175-32183. PMID: 34184868
  5. The electrochemical fluorination of octanoyl chloride  |  , et al. (1979)Cite this article. Journal of Applied Electrochemistry. volume 9,: pages 685–697.
  6. Yield improvements in the electrochemical production of perfluorooctanoic acid  |  M Napoli, A Scipioni, C Fraccaro, E Legnaro…. Page 227. Journal of Fluorine Chemistry. Volume 58, Issues 2–3,: August–September 1992,.
  7. The electrochemical fluorination of octanoyl fluoride with electrolyte circulation  |  D Lines, H Sutcliffe. May 1981,. Journal of Fluorine Chemistry. Volume 17, Issue 5,: Pages 423-439.
  8. Analysis of the products from the electrochemical fluorination of octanoyl chloride  |  HW Prokop, HJ Zhou, SQ Xu, CH Wu, CC Liu. May 1989. Journal of Fluorine Chemistry. Volume 43, Issue 2,:, Pages 277-290.
  9. Process improvements in the electrochemical fluorination of octanoyl chloride  |  HW Prokop, HJ Zhou, SQ Xu, CH Wu, SR Chuey. May 1989,. Journal of Fluorine Chemistry. Volume 43, Issue 2,: Pages 257-275.
  10. Electrochemical fluorination of 4-(perfluoro-n-butyl)-n-butanoyl chloride  |  M Napoli, L Conte, GP Gambaretto. November 1989,. Journal of Fluorine Chemistry. Volume 45, Issue 2,: Pages 213-224.
  11. Kinetics of Decomposition of PFOS Relevant to Thermal Desorption Remediation of Soils  |  Nathan H. Weber, Sebastian P. Stockenhuber, Cameron S. Delva, Ammar Abu Fara, Charles C. Grimison, John A. Lucas, John C. Mackie*, Michael Stockenhuber, and Eric M. Kennedy*. 2021. nd. Eng. Chem. Res., 60, 25,: 9080–9087.
  12. Arginine-rich peptide based nanoparticles with bridge-like structure: Enhanced cell penetration and tumor therapy effect  |  X Yan, L Lin, S Li, W Wang, B Chen, S Jiang…., 1 September 2020,. Chemical Engineering Journal. Volume 395: 125171.
  13. A Lewis acid catalytic process for preparing fluorocarboxylic acid halides  |  FE Behr, Y Cheburkov. 28 December 2001,. Journal of Fluorine Chemistry. Volume 112, Issue 2,: Pages 367-370.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Perfluorooctanoyl fluoride, 5 g

sc-264055
5 g
$294.00

Perfluorooctanoyl fluoride, 25 g

sc-264055A
25 g
$682.00