Date published: 2026-5-1

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Perfluorononanoic acid (CAS 375-95-1)

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Alternate Names:
Heptadecafluorononanoic acid
CAS Number:
375-95-1
Purity:
≥97%
Molecular Weight:
464.08
Molecular Formula:
C9HF17O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Perfluorononanoic acid is focused on environmental chemistry and toxicology, particularly concerning the persistence and bioaccumulation of perfluorinated compounds. Perfluorononanoic acid is instrumental in studies that examine the environmental fate of fluorinated organic chemicals, including their degradation and interaction with various ecosystems. Some use Perfluorononanoic acid to understand its distribution and impact on water and soil systems, which helps in assessing potential environmental risks. Perfluorononanoic acid is utilized in the development of advanced filtration and remediation techniques aimed at removing persistent organic pollutants from contaminated sites. Studies involving Perfluorononanoic acid also contribute to the understanding of molecular mechanisms underlying the bioactivity of fluorinated compounds.


Perfluorononanoic acid (CAS 375-95-1) References

  1. Perfluorononanoic acid induces apoptosis involving the Fas death receptor signaling pathway in rat testis.  |  Feng, Y., et al. 2009. Toxicol Lett. 190: 224-30. PMID: 19646514
  2. Developmental toxicity of perfluorononanoic acid in mice.  |  Das, KP., et al. 2015. Reprod Toxicol. 51: 133-44. PMID: 25543169
  3. Acute Immunotoxic Effects of Perfluorononanoic Acid (PFNA) in C57BL/6 Mice.  |  Rockwell, CE., et al. 2013. Clin Exp Pharmacol. Suppl 4: PMID: 25568816
  4. Perfluorononanoic acid in combination with 14 chemicals exerts low-dose mixture effects in rats.  |  Hadrup, N., et al. 2016. Arch Toxicol. 90: 661-75. PMID: 25588985
  5. Toxic effects of perfluorononanoic acid on the development of Zebrafish (Danio rerio) embryos.  |  Liu, H., et al. 2015. J Environ Sci (China). 32: 26-34. PMID: 26040728
  6. Alteration of Bile Acid and Cholesterol Biosynthesis and Transport by Perfluorononanoic Acid (PFNA) in Mice.  |  Zhang, Y., et al. 2018. Toxicol Sci. 162: 225-233. PMID: 29112762
  7. Chronic exposure to perfluorononanoic acid impairs spermatogenesis, steroidogenesis and fertility in male mice.  |  Singh, S. and Singh, SK. 2019. J Appl Toxicol. 39: 420-431. PMID: 30294798
  8. Perfluorononanoic acid (PFNA) alters lipid accumulation in bovine blastocysts after oocyte exposure during in vitro maturation.  |  Hallberg, I., et al. 2019. Reprod Toxicol. 84: 1-8. PMID: 30502403
  9. Prepubertal exposure to perfluorononanoic acid interferes with spermatogenesis and steroidogenesis in male mice.  |  Singh, S. and Singh, SK. 2019. Ecotoxicol Environ Saf. 170: 590-599. PMID: 30576894
  10. Effect of gestational exposure to perfluorononanoic acid on neonatal mice testes.  |  Singh, S. and Singh, SK. 2019. J Appl Toxicol. 39: 1663-1671. PMID: 31389053
  11. Acute exposure to perfluorononanoic acid in prepubertal mice: Effect on germ cell dynamics and an insight into the possible mechanisms of its inhibitory action on testicular functions.  |  Singh, S. and Singh, SK. 2019. Ecotoxicol Environ Saf. 183: 109499. PMID: 31398581
  12. Supramolecular self-assembly of the γ-cyclodextrin and perfluorononanoic acid system in aqueous solution.  |  Zhang, J., et al. 2021. Soft Matter. 17: 1428-1436. PMID: 33325964
  13. An 'Omics Approach to Unraveling the Paradoxical Effect of Diet on Perfluorooctanesulfonic Acid (PFOS) and Perfluorononanoic Acid (PFNA)-Induced Hepatic Steatosis.  |  Pfohl, M., et al. 2021. Toxicol Sci. 180: 277-294. PMID: 33483757
  14. Perfluorononanoic acid impedes mouse oocyte maturation by inducing mitochondrial dysfunction and oxidative stress.  |  Jiao, X., et al. 2021. Reprod Toxicol. 104: 58-67. PMID: 34246765
  15. Perfluorononanoic Acid Induces Neurotoxicity via Synaptogenesis Signaling in Zebrafish.  |  Liu, S., et al. 2023. Environ Sci Technol. 57: 3783-3793. PMID: 36797597

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Perfluorononanoic acid, 5 g

sc-250678
5 g
$62.00

Perfluorononanoic acid, 25 g

sc-250678A
25 g
$164.00